NDLI: The rat closely mimics oxidative stress and inflammation in humans after exercise but not after exercise combined with vitamin C administration

Content Provider	Springer Nature Link
Author	Veskoukis, Aristidis S. Goutias, Georgios Paschalis, Vassilis Margaritelis, Nikos V. Tzioura, Aikaterini Dipla, Konstantina Zafeiridis, Andreas Vrabas, Ioannis S. Kyparos, Antonios Nikolaidis, Michalis G.
Copyright Year	2016
Abstract	The purpose of the present study was to directly compare oxidative stress and inflammation responses between rats and humans.We contrasted rat and human oxidative stress and inflammatory responses to exercise (pro-oxidant stimulus) and/or vitamin C (anti-oxidant stimulus) administration. Vitamin C was administered orally in both species (16 mg kg−1 of body weight). Twelve redox biomarkers and seven inflammatory biomarkers were determined in plasma and erythrocytes pre- and post-exercise or pre- and post-exercise combined with vitamin C administration.Exercise increased oxidative stress and induced an inflammatory state in rats and humans. There were only 1/19 significant species × exercise interactions (catalase), indicating similar responses to exercise between rats and humans in redox and inflammatory biomarkers. Vitamin C decreased oxidative stress and increased antioxidant capacity only in humans and did not affect the redox state of rats. In contrast, vitamin C induced an anti-inflammatory state only in rats and did not affect the inflammatory state of humans. There were 10/19 significant species × vitamin C interactions, indicating that rats poorly mimic human oxidative stress and inflammatory responses to vitamin C administration. Exercise after acute vitamin C administration altered redox state only in humans and did not affect the redox state of rats. On the contrary, inflammation biomarkers changed similarly after exercise combined with vitamin C in both rats and humans.The rat adequately mimics human responses to exercise in basic blood redox/inflammatory profile, yet this is not the case after exercise combined with vitamin C administration.
Starting Page	791
Ending Page	804
Page Count	14
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	116
Issue Number	4
e-ISSN	14396327
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-02-08
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Animal models Biomarkers Exercise Human Rat Vitamin C Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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