NDLI: Haptoglobin genotype and endothelial function in diabetes mellitus: a pilot study

Content Provider	Springer Nature Link
Author	Dayan, Lior Levy, Andrew P. Blum, Shany Miller Lotan, Rachel Melman, Uzi Alshiek, Jonia Jacob, Giris
Copyright Year	2009
Abstract	Endothelial function (EnF) is impaired in patients with diabetes mellitus (DM) due in large part to an increase in oxidative stress. Haptoglobin (Hp) is a potent antioxidant protein which is encoded by two different alleles (1 and 2) with the Hp 1 protein being a superior antioxidant to the Hp 2 protein. We hypothesized that DM individuals with the Hp 2-2 genotype would have greater endothelial dysfunction as compared to DM individuals with the Hp 1-1 genotype. We studied EnF in 16 Hp 2-2, 14 Hp 1-1 DM individuals and 14 healthy subjects. DM patients’ groups were matched in terms of age, cardiovascular risk factors and metabolic characteristics. EnF was assessed using post-ischemic reactive hyperemia and strain gauge plethysmography and expressed either as the maximal flow after the ischemic period or as the area under the flow–time curve (AUC). We showed that EnF indices, AUC and maximal flow, were also higher in the healthy and Hp 1-1 groups compared with Hp 2-2 genotype group (615 ± 60 and 600 ± 40 vs. 450 ± 50 ml dl−1, 29 ± 2.6 and 25 ± 3 vs. 14 ± 1.8 ml min−1 dl−1, P < 0.003 and P < 0.05, for AUC and maximal flow, one-way ANOVA, respectively). We concluded that Hp 2-2 diabetic patients had a worse EnF than controls and Hp 1-1 diabetic subjects.
Starting Page	639
Ending Page	644
Page Count	6
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	106
Issue Number	4
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-04-04
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Endothelial function Haptoglobin Reactive hyperemia Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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