NDLI: Differential atrophy of the lower-limb musculature during prolonged bed-rest

Content Provider	Springer Nature Link
Author	Belavý, Daniel L. Miokovic, Tanja Armbrecht, Gabriele Richardson, Carolyn A. Rittweger, Jörn Felsenberg, Dieter
Copyright Year	2009
Abstract	Patients with medical, orthopaedic and surgical conditions are often assigned to bed-rest and/or immobilised in orthopaedic devices. Although such conditions lead to muscle atrophy, no studies have yet considered differential atrophy of the lower-limb musculature during inactivity to enable the development of rehabilitative exercise programmes. Bed-rest is a model used to simulate the effects of spaceflight and physical inactivity. Ten male subjects underwent 56-days of bed-rest. Magnetic resonance imaging of the lower-limbs was performed at 2-weekly intervals during bed-rest. Volume of individual muscles of the lower-limb and subsequently, rates of atrophy were calculated. Rates of atrophy differed (F = 7.4, p < 0.0001) between the muscles with the greatest rates of atrophy seen in the medial gastrocnemius, soleus and vastii (p < 0.00000002). The hamstring muscles were also affected (p < 0.00015). Atrophy was less in the ankle dorsiflexors and anteromedial hip muscles (p > 0.081). Differential rates of atrophy were seen in synergistic muscles (e.g. adductor magnus > adductor longus, p = 0.009; medial gastrocnemius > lateral gastrocnemius, p = 0.002; vastii > rectus femoris, p = 0.0002). These results demonstrate that muscle imbalances can occur after extended periods of reduced postural muscle activity, potentially hampering recovery on return to full upright body position. Such deconditioned patients should be prescribed “closed-chain” simulated resistance exercises, which target the lower-limb antigravity extensor muscles which were most affected in bed-rest.
Starting Page	489
Ending Page	499
Page Count	11
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	107
Issue Number	4
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-08-13
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Berlin Bed Rest Study Magnetic resonance imaging Microgravity Muscle atrophy Sports Medicine Occupational Medicine/Industrial Medicine Human Physiology
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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