NDLI: Myocardial tolerance to ischemia–reperfusion injury, training intensity and cessation

Content Provider	Springer Nature Link
Author	Esposito, Fabio Ronchi, Raffaella Mila, Giuseppina Margonato, Vittoria Tullio, Simona Marini, Marina Veicsteinas, Arsenio Samaja, Michele
Copyright Year	2010
Abstract	Training has been shown to induce cardioprotection. The mechanisms involved remain still poorly understood. Aims of the study were to examine the relevance of training intensity on myocardial protection against ischemia/reperfusion (I/R) injury, and to which extent the beneficial effects persist after training cessation in rats. Sprague-Dawley rats trained at either low (60% $$ {\dot{{V}}\text{O}}_{2\max } $$ ) or high (80% $$ {\dot{{V}}\text{O}}_{2\max } $$ ) intensity for 10 weeks. An additional group of highly trained rats was detrained for 4 weeks. Untrained rats served as controls. At the end of treatment, rats of all groups were split into two subgroups. In the former, rats underwent left anterior descending artery (LAD) ligature for 30 min, followed by 90-min reperfusion, with subsequent measurement of the infarct size. In the latter, biopsies were taken to measure heat-shock proteins (HSP) 70/72, vascular endothelial growth factor (VEGF) protein levels, and superoxide dismutase (SOD) activity. Training reduced infarct size proportionally to training intensity. With detraining, infarct size increased compared to highly trained rats, maintaining some cardioprotection with respect to controls. Cardioprotection was proportional to training intensity and related to HSP70/72 upregulation and Mn-SOD activity. The relationship with Mn-SOD was lost with detraining. VEGF protein expression was not affected by either training or detraining. Stress proteins and antioxidant defenses might be involved in the beneficial effects of long-term training as a function of training intensity, while HSP70 may be one of the factors accounting for the partial persistence of myocardial protection against I/R injury in detrained rats.
Starting Page	859
Ending Page	868
Page Count	10
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	111
Issue Number	5
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-11-10
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Exercise HSP70 VEGF Mn-SOD Cardioprotection Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mild exercise training, cardioprotection and stress genes profile

The greater effect of high-intensity interval training versus moderate-intensity continuous training on cardioprotection against ischemia-reperfusion injury through Klotho levels and attenuate of myocardial TRPC6 expression

Aerobic exercise training induces superior cardioprotection following myocardial ischemia reperfusion injury than a single aerobic exercise session in rats

Interval training in the boundaries of severe domain: effects on aerobic parameters

Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery

Resistance exercise effects on blood glutathione status and plasma protein carbonyls: influence of partial vascular occlusion

Effects of exercise intensity and occlusion pressure after 12 weeks of resistance training with blood-flow restriction

Alterations in peripheral muscle contractile characteristics following high and low intensity bouts of exercise

Effects of mild-exercise training cessation in human skeletal muscle

Myocardial tolerance to ischemia–reperfusion injury, training intensity and cessation

Similar Documents

Mild exercise training, cardioprotection and stress genes profile

The greater effect of high-intensity interval training versus moderate-intensity continuous training on cardioprotection against ischemia-reperfusion injury through Klotho levels and attenuate of myocardial TRPC6 expression

Aerobic exercise training induces superior cardioprotection following myocardial ischemia reperfusion injury than a single aerobic exercise session in rats

Interval training in the boundaries of severe domain: effects on aerobic parameters

Effect of exercise intensity on post-exercise oxygen consumption and heart rate recovery

Resistance exercise effects on blood glutathione status and plasma protein carbonyls: influence of partial vascular occlusion

Effects of exercise intensity and occlusion pressure after 12 weeks of resistance training with blood-flow restriction

Alterations in peripheral muscle contractile characteristics following high and low intensity bouts of exercise

Effects of mild-exercise training cessation in human skeletal muscle

Myocardial tolerance to ischemia–reperfusion injury, training intensity and cessation