NDLI: The influence of exercise training status on antigen-stimulated IL-10 production in whole blood culture and numbers of circulating regulatory T cells

Content Provider	Springer Nature Link
Author	Handzlik, Michal K. Shaw, Andrew J. Dungey, Maurice Bishop, Nicolette C. Gleeson, Michael
Copyright Year	2013
Abstract	Highly trained athletes are associated with high resting antigen-stimulated whole blood culture interleukin (IL)-10 production. The purpose of the present study was to examine the effects of training status on resting circulating T regulatory (Treg) cell counts and antigen-stimulated IL-10 production and the effect of acute bout of exercise on the Treg response. Forty participants volunteered to participate and were assigned to one of the four groups: sedentary (SED), recreationally active (REC), sprint-trained athletes and endurance-trained athletes (END). From the resting blood sample, CD4+CD25+CD127low/− Treg cells and in vitro antigen-stimulated IL-10 production were assessed. Ten REC subjects performed 60 min cycling at 70 % of maximal oxygen uptake and blood samples for Treg analysis were collected post- and 1 h post-exercise. IL-10 production was greater in END compared with the other groups (P < 0.05). END had a higher Treg percentage of total lymphocyte count compared with SED (P < 0.05). A smaller proportion of Treg CD4+ cells were observed in SED compared with all other groups (P < 0.05). IL-10 production significantly correlated with the proportion of Tregs within the total lymphocyte population (r s = 0.51, P = 0.001). No effect of acute exercise was evident for Treg cell counts in the REC subjects (P > 0.05). Our results demonstrate that high training loads in END are associated with greater resting IL-10 production and Treg cell count and suggest a possible mechanism for depression of immunity commonly reported in athletes engaged in high training loads.
Starting Page	1839
Ending Page	1848
Page Count	10
File Format	PDF
ISSN	14396319
Journal	European Journal of Applied Physiology
Volume Number	113
Issue Number	7
e-ISSN	14396327
Language	English
Publisher	Springer-Verlag
Publisher Date	2013-02-23
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Interleukin-10 T regulatory cells Immune system Exercise Training Human Physiology Occupational Medicine/Industrial Medicine Sports Medicine
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physiology (medical) Public Health, Environmental and Occupational Health Sports Science

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