NDLI: Time courses and variability of pyrethroid biomarkers of exposure in a group of agricultural workers in Quebec, Canada

Content Provider	Springer Nature Link
Author	Ratelle, Mylène Côté, Jonathan Bouchard, Michèle
Copyright Year	2016
Abstract	Cypermethrin is a pyrethroid pesticide widely used in agriculture. Exposure can be assessed through biomonitoring. However, interpretation of results requires a proper knowledge of the toxicokinetics of the exposure biomarkers of interest. This study aimed at characterizing typical urinary time courses of biomarkers of exposure to cypermethrin in farm workers in Quebec following an exposure episode, distribution of values and variability, and predictors of elevated excretion levels.Workers provided total voids before seasonal spraying and during three consecutive days following an exposure period. Personal factors, professional tasks, and exposure conditions were documented by questionnaire. The urinary metabolites cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (DCCA) and 3-phenoxybenzoic acid (3-PBA) were quantified.Time courses showed significant variations of metabolite levels through time, although a clear profile typical of an acute exposure episode was not observed for several workers. However, maximum urinary levels in most exposed workers were generally reached 18–32 h following the onset of an exposure episode. Group comparison showed that applicators had higher excretions than workers performing inspection, harvest, or weeding.Time-dependent variations in excretions indicate the importance of serial urinary collections for a proper interpretation of a worker exposure pattern. In the context of group comparison, the alternative based on observed time courses and peak levels in most exposed workers would be the collection of urine samples prior to an exposure episode, at the end-of-shift after exposure onset and following morning void. When spot samples can only be collected for population exposure assessment, Monte Carlo simulations showed that iterative random selection of single urinary values from individual time courses observed in this study to predict distribution of values in the group of workers converged to similar central tendencies.
Starting Page	767
Ending Page	783
Page Count	17
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	89
Issue Number	5
e-ISSN	14321246
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-02-01
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pyrethroids Cypermethrin Toxicokinetics Occupational health DCCA 3-PBA Environmental Health Rehabilitation Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Detailed Urinary Excretion Time Courses of Biomarkers of Exposure to Permethrin and Estimated Exposure in Workers of a Corn Production Farm in Quebec, Canada

A longitudinal approach to assessing urban and suburban children's exposure to pyrethroid pesticides.

Biological monitoring of exposure and effects in workers employed in a selenium-processing plant

Occupational paraquat exposure of agricultural workers in large Costa Rican farms

Healthy worker survivor analysis in an occupational cohort study of Dutch agricultural workers

Evaluation of biomarkers of occupational exposure to toluene at low levels

Biomarkers of inflammation in workers exposed to compost and sewage dust

Evaluation of exposure biomarkers in offshore workers exposed to low benzene and toluene concentrations

Characterization of α-cypermethrin Exposure in Egyptian Agricultural Workers

Time courses and variability of pyrethroid biomarkers of exposure in a group of agricultural workers in Quebec, Canada

Similar Documents

Detailed Urinary Excretion Time Courses of Biomarkers of Exposure to Permethrin and Estimated Exposure in Workers of a Corn Production Farm in Quebec, Canada

A longitudinal approach to assessing urban and suburban children's exposure to pyrethroid pesticides.

Biological monitoring of exposure and effects in workers employed in a selenium-processing plant

Occupational paraquat exposure of agricultural workers in large Costa Rican farms

Healthy worker survivor analysis in an occupational cohort study of Dutch agricultural workers

Evaluation of biomarkers of occupational exposure to toluene at low levels

Biomarkers of inflammation in workers exposed to compost and sewage dust

Evaluation of exposure biomarkers in offshore workers exposed to low benzene and toluene concentrations

Characterization of α-cypermethrin Exposure in Egyptian Agricultural Workers

Time courses and variability of pyrethroid biomarkers of exposure in a group of agricultural workers in Quebec, Canada