NDLI: Cardiovascular function of workers exposed to carbon disulphide

Content Provider	Springer Nature Link
Author	Korinth, G. Göen, T. Ulm, K. Hardt, R. Hubmann, M. Drexler, H.
Copyright Year	2003
Abstract	Objectives. The aim of the study was to verify that exposure to carbon disulphide (CS2) up to 10 ppm results in a negative inotropic effect on cardiovascular function. Methods. In a cross-sectional study a total of 325 workers exposed to CS2 in the rayon-producing industry and 179 controls from the same plants were examined. The exposure assessment was based on personal air sampling and biological monitoring (2-thiothiazolidine-4-carboxylic acid (TTCA) in urine) for all persons. The examination consisted of a standardised questionnaire, physical examination, assessment of body fat mass, ergometric test with the determination of work capacity at heart rates of 100, 130, 150 and 170 beats/min, and electrocardiography. Results. The mean external exposure was 6.04 ppm CS2 (range: 0.03–91.08); the mean internal exposure was 1.14 mg TTCA/g creatinine (range: 0.02–11.50). The workers exposed to CS2 showed better physical fitness. The diameters of the left heart chamber of the exposed persons were not significantly different when compared with occupationally non-exposed workers, but there was a tendency of increasing diameters for the exposed employees. In the multiple linear regression the diameters showed physiologically plausible correlations with the body mass index, body fat mass, alcohol consumption, and physical fitness, but not, however, with the exposure, neither with the exposure group in all persons nor with the internal or external exposure within the exposed workers. Conclusions. In this study, differences in the heart chamber diameters between exposed persons and controls could not be confirmed. Differences in physical fitness and constitution can explain differences in heart chamber diameters.
Starting Page	81
Ending Page	85
Page Count	5
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	76
Issue Number	1
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2002-10-12
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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