NDLI: Experimental exposure of healthy subjects with emissions from a gas metal arc welding process—part II: biomonitoring of chromium and nickel

Content Provider	Springer Nature Link
Author	Gube, Monika Brand, Peter Schettgen, Thomas Bertram, Jens Gerards, Kerstin Reisgen, Uwe Kraus, Thomas
Copyright Year	2012
Abstract	The objective of this study was to investigate whether there is a relationship between the external exposure dose of chromium and nickel caused by a metal active gas welding process with a solid high-alloyed steel welding wire and inner exposure of subjects. In order to perform welding fume exposure under controlled and standardized conditions, the investigations were conducted in the “Aachen Workplace Simulation Laboratory”.To perform biological monitoring of chromium and nickel, blood and urine samples of 12 healthy male non-smokers who never worked as welders were collected before and after a 6-h exposure to ambient air (0 mg/m3) and to welding fumes of a metal active gas welding process once with a concentration of the welding fume of 1 mg/m3 and once with a concentration of 2.5 mg/m3.Although the internal exposure to chromium and nickel in this study was comparatively low, the subjects showed significantly increased concentrations of these metals in urine after exposure to welding fume compared to the values at baseline. Moreover, the observed increase was significantly dose dependent for both of the substances.For the biological monitoring of chromium and nickel in urine of subjects exposed to welding fumes, a dependency on exposure dose was seen under standardized conditions after a single exposure over a period of 6 h. Thus, this study contributes to a better understanding of the relationship between ambient and biological exposures from welding fumes and provides a good basis for evaluating future biological threshold values for these metals in welding occupation.
Starting Page	31
Ending Page	37
Page Count	7
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	86
Issue Number	1
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-02-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Welding Biomonitoring High alloy steel Chromium Nickel Environmental Health Rehabilitation Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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