NDLI: Evaluation of peripheral blood neutrophil leucocytes in lead-exposed workers

Content Provider	Springer Nature Link
Author	Di Lorenzo, Luigi Silvestroni, Andrea Marti, Maria Giuliana Gagliardi, Tommaso Corfiati, Marisa Soleo, Leonardo
Copyright Year	2006
Abstract	Background: Inorganic lead can interfere with humoral and especially cell-mediated immunity even at frequently occurring (<50 μg/dl) blood lead (Pb-B) levels. Occupational exposure to lead causes a primary impairment of the chemotactic and phagocytic activities of neutrophil leucocytes. Objective: To verify whether, after taking into account the main confounding factors, occupational lead exposure is shown to induce changes in the number of blood neutrophil leucocytes, and to assess a possible dose-response relationship between Pb-B and the circulating neutrophil count in exposed workers. Subjects and methods: The study included 68 male lead-exposed (E) workers and 59 male workers in a food plant, recruited as controls (NE). A standardized questionnaire probing work, social, familial and personal medical history was administered to all the subjects. Blood and urine samples were collected to determine the dose and effect biological indices of lead and the total white blood cell and neutrophil counts. Results: Pb-B levels were significantly higher in E (geometric mean (GM): 20.5 μg/dl; 3.2–120 μg/dl) than in NE workers (GM: 3.5 μg/dl; 1–11 μg/dl). The mean absolute neutrophil count (ANC) was significantly higher in E workers with respect to NE workers. ANC correlated significantly with the biological lead dose and effect indices. Moreover, there was a dose-dependent increase of ANC with increasing Pb-B levels. The linear relationship between ANC and Pb-B was confirmed even after correction for age, body mass index and smoking habit. We also found an interaction between Pb-B level and smoking habit in increasing the number of blood neutrophils in lead-exposed workers. Conclusion: Our study is the first to describe a dose-dependent effect of lead on ANC in exposed workers. Our results underline the importance of promoting a further reduction of occupational lead exposure levels, adopting adequate individual protection means, as well as conducting medical campaigns against smoking, at the workplace.
Starting Page	491
Ending Page	498
Page Count	8
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	79
Issue Number	6
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-01-17
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Inorganic lead Occupational exposure Immunotoxicological effects Absolute neutrophil count (ANC)
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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