NDLI: No significant effect of iron deficiency on cadmium body burden or kidney dysfunction among women in the general population in Japan

Content Provider	Springer Nature Link
Author	Tsukahara, T. Ezaki, T. Moriguchi, J. Furuki, K. Fukui, Y. Ukai, H. Okamoto, S. Sakurai, H. Ikeda, M.
Copyright Year	2003
Abstract	Objective. To examine if iron-deficient conditions modify body burden or health effects of cadmium among women in the general population in Japan. Methods. In 2002, 1,482 women aged 20 to 74 years in six prefectures in Japan provided informed consent to participate in this study. They offered peripheral blood and spot urine samples, and answered questionnaires on their social habits and health conditions. Never-smoking, non-pregnant and non-lactating healthy women (1,190 subjects) were selected from the volunteers. Blood samples were analyzed for serum iron, ferritin and total iron-binding capacity (TIBC) in addition to red blood cell (RBC) counts and hemoglobin (Hb) concentration as markers of anemia and iron deficiency. Urine samples were analyzed for cadmium (Cd), α1-microglobulin (α1-MG), β2-microglobulin (β2-MG) as markers of Cd burden and Cd-induced tubular dysfunction; the measures were expressed after being corrected for creatinine (cr) as, e.g., Cd-Ucr. Results. The subjects were classified into anemic (37 women) and iron-deficient (388 women) groups separately from healthy controls (765 women), taking ferritin (<20 ng/ml) and Hb (<10 g/100 ml) as classification indicators. Strictly matched pairs (with regard to age and prefecture) were established for 36 anemic and 280 iron-deficient cases. Comparison between the cases and the matched controls showed that serum iron was lower and TIBC was higher in accordance with lower levels of ferritin and Hb in the anemic and iron-deficient groups, although the RBC count was only slightly reduced (the anemic group) or stayed essentially unchanged (the iron-deficient group). In contrast, no significant increase in Cd-Ucr, α1-MG, or β2-MG was observed in either the anemic group or the iron-deficient group compared with the matched controls. Cd-Ucr in one case of clinical anemia, however, tended to be higher than the levels among women of the same age range and from the same prefecture. Her α1-MG-Ucr and β2-MG-Ucr, however, remained un-elevated. Conclusions. The current level of iron deficiency among women in the general population in Japan may not induce significant increase in Cd body burden or Cd-induced tubular dysfunction.
Starting Page	275
Ending Page	281
Page Count	7
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	76
Issue Number	4
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-04-29
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Effects of aging on cadmium and tubular dysfunction markers in urine from adult women in non-polluted areas

Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan

No clear-cut evidence for cadmium-induced renal tubular dysfunction among over 10,000 women in the Japanese general population: a nationwide large-scale survey

Correlation between urine and blood concentrations, and dietary intake of cadmium and lead among women in the general population of Japan

Relation of child birth and breast-feeding burden with cadmium and tubular dysfunction marker levels in urine of adult women in non-polluted areas in Japan

Analysis for threshold levels of cadmium in urine that induce tubular dysfunction among women in non-polluted areas in Japan

The influence of iron stores on cadmium body burden in a Thai population

Possible effects of environmental cadmium exposure on kidney function in the Japanese general population

Correlation among cadmium levels in river sediment, in rice, in daily foods and in urine of residents in 11 prefectures in Japan

No significant effect of iron deficiency on cadmium body burden or kidney dysfunction among women in the general population in Japan

Similar Documents

Effects of aging on cadmium and tubular dysfunction markers in urine from adult women in non-polluted areas

Closer correlation of cadmium in urine than that of cadmium in blood with tubular dysfunction markers in urine among general women populations in Japan

No clear-cut evidence for cadmium-induced renal tubular dysfunction among over 10,000 women in the Japanese general population: a nationwide large-scale survey

Correlation between urine and blood concentrations, and dietary intake of cadmium and lead among women in the general population of Japan

Relation of child birth and breast-feeding burden with cadmium and tubular dysfunction marker levels in urine of adult women in non-polluted areas in Japan

Analysis for threshold levels of cadmium in urine that induce tubular dysfunction among women in non-polluted areas in Japan

The influence of iron stores on cadmium body burden in a Thai population

Possible effects of environmental cadmium exposure on kidney function in the Japanese general population

Correlation among cadmium levels in river sediment, in rice, in daily foods and in urine of residents in 11 prefectures in Japan

No significant effect of iron deficiency on cadmium body burden or kidney dysfunction among women in the general population in Japan