NDLI: Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium

Content Provider	Springer Nature Link
Author	Seidler, Andreas Jähnichen, Sabine Hegewald, Janice Fishta, Alba Krug, Olga Rüter, Luisa Strik, Claudia Hallier, Ernst Straube, Sebastian
Copyright Year	2012
Abstract	To investigate the exposure-risk relationship for occupational chromium (VI) exposure and lung cancer in order to establish exposure limits.We systematically searched for studies reporting on occupational Cr(VI) exposure and cancers of the respiratory tract. To be included, studies needed to provide data for more than one level of occupational Cr(VI) exposure, adequately consider the confounder smoking and be of adequate methodological quality. Because direct genotoxicity was considered the predominant mechanism of carcinogenesis of Cr(VI), linear models were applied in order to fit risk data. Relative risks were calculated based on these linear regression models and then used to estimate excess absolute risks.Five studies of two cohorts of chromium production workers in Baltimore, Maryland, and Painesville, Ohio, were included. Based on different estimates for the exposure effect, the absolute excess risk was found to be “acceptable” (less than 4 per 10,000 according to the German Committee on Hazardous Substances, “AGS”) at a Cr(VI) concentration of 0.1 μg/m3, and became “intolerable” (more than 4 per 1,000) beyond a Cr(VI) concentration of 1 μg/m3.Occupational exposure limits for Cr(VI) based on excess absolute risks can be derived from published data identified by a systematic literature review.
Starting Page	943
Ending Page	955
Page Count	13
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	86
Issue Number	8
e-ISSN	14321246
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2012-10-19
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Chromium Occupational exposure Systematic review Exposure-risk relationship Environmental Health Rehabilitation Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Re: Seidler A, Jänichen S, Hegewald J et al. Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium

Reply to: Pesch B, Weiss T, Pallapies D, Schlüter G, Brüning T. Letter to the editor. Re: Seidler A, Jähnichen S, Hegewald J, Fishta A, Krug O, Rüter L, Strik C, Hallier E, Straube S. Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium

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