NDLI: A meta-analysis of occupational trichloroethylene exposure and liver cancer

Content Provider	Springer Nature Link
Author	Alexander, Dominik D. Kelsh, Michael A. Mink, Pamela J. Mandel, Jeffrey H. Basu, Rupa Weingart, Michal
Copyright Year	2007
Abstract	Findings from epidemiologic studies of trichloroethylene (TCE) exposure and liver cancer have been inconsistent. To quantitatively evaluate this association and to examine sources of heterogeneity, we conducted a meta-analysis of occupational studies of TCE exposure and liver/biliary tract cancer.We identified 14 occupational cohort studies of TCE exposed workers and one case-control study that met our inclusion criteria. Nine studies specifically identified TCE as a workplace exposure, and were classified as Group I cohort studies. Subcohorts of workers, identified within eight of these studies as more likely exposed to TCE than the total cohort, were analyzed separately.The combined liver/biliary cancer summary relative risk estimate (SRRE) for all studies was 1.08 (95% CI 0.91–1.29; heterogeneity (H)-P-value = 0.12). For the total study populations in the Group I cohorts, the SRRE was 1.14 (95% CI 0.93–1.39; H-P-value = 0.05) and for the subcohorts, the SRRE was 1.30 (95% CI 1.09–1.55). Within this subcohort analysis, the association for the European studies of workers from various industries (SRRE = 1.38; based on four studies) was higher than the association for the US studies of aerospace and aircraft workers (SRRE = 0.97, based on four studies).Although positive associations were observed for some analyses, results were inconsistent across occupational groups (aerospace/aircraft vs. other industries combined), study location, and incidence versus mortality endpoints. In addition, exposure-response trends were not observed consistently across studies. Interpretation is also limited by the potential impact of uncontrolled confounding by other occupational or lifestyle exposures such as smoking or alcohol consumption. Given these limitations, the currently available epidemiologic data are not sufficient to support a causal relation between occupational TCE exposure and liver/biliary cancer.
Starting Page	127
Ending Page	143
Page Count	17
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	81
Issue Number	2
e-ISSN	14321246
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-05-10
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Rehabilitation Environmental Health Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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