NDLI: Urinary creatinine concentrations in an industrial workforce and comparison with reference values of the general population

Content Provider	Springer Nature Link
Author	Bader, Michael Messerer, Peter Will, Wolfgang
Copyright Year	2012
Abstract	Urinary creatinine is an important parameter for the adjustment of metabolite concentrations in differently diluted urine specimens, as a reference dimension for biological limit or guidance values and as a selection criterion for spot urine samples in human biomonitoring. While the creatinine output of the general population has been well described in environmental surveys, this study focused specifically on creatinine concentrations in a large industrial workforce in order to compare these data with the general population and to provide a database for the calculation of a reasonable conversion factor between volume-related and creatinine-adjusted data and vice versa.Urinary creatinine was analysed in 6,438 spot urine samples by a photometric assay in the time period between 1989 and 2009. Basic demographic data (age, sex, body weight, body height) and job category (apprentices, skilled craftsmen, skilled chemical workers, foremen, laboratory staff and executives) were considered in a statistical analysis.The median concentration of urinary creatinine in all urine samples was 1.36 g/L with male employees showing significantly higher values (1.37 g/L, n = 6,148 samples) than female employees (1.00 g/L, n = 290) and concentrations ranging from 0.01 up to 9.76 g/L. Age, body mass index and job category were significant influence factors on urinary creatinine. About 92 % of all samples showed creatinine concentrations between 0.3 and 3.0 g/L, a range recommended by the World Health Organization as a criterion for valid spot urine samples.The results of this study correspond well with data from environmental surveys and with recent data from an active workforce in industry with similar sampling strategies. Therefore, a median of 1.4 g creatinine per litre urine seems to be a reasonable value for general calculations and adjustments. The study data also support the validity of the current recommendations by the WHO and several scientific committees and institutions with respect to creatinine limits in spot urine samples for occupational-medical biomonitoring.
Starting Page	673
Ending Page	680
Page Count	8
File Format	PDF
ISSN	03400131
Journal	International Archives of Occupational and Environmental Health
Volume Number	86
Issue Number	6
e-ISSN	14321246
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2012-08-07
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Creatinine Biomonitoring Urinalysis Occupational toxicology Environmental Health Rehabilitation Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone

Worrying exposure to trace elements in the population of Kinshasa, Democratic Republic of Congo (DRC)

Biological reference values for chemical compounds in the work area (BARs): an approach for evaluating biomonitoring data

Biomonitoring of exposure to nitrous oxide, sevoflurane, isoflurane and halothane by automated GC/MS headspace urinalysis

Occupational exposure of cashiers to Bisphenol A via thermal paper: urinary biomonitoring study

Comparison of urinary thallium levels in non-occupationally exposed people and workers

Biomonitoring of two types of chromium exposure in an electroplating shop

Reference values for cobalt, copper, manganese, and nickel in urine among women of the general population in Japan

Reproductive toxicology in occupational settings: an update

Urinary creatinine concentrations in an industrial workforce and comparison with reference values of the general population

Similar Documents

Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone

Worrying exposure to trace elements in the population of Kinshasa, Democratic Republic of Congo (DRC)

Biological reference values for chemical compounds in the work area (BARs): an approach for evaluating biomonitoring data

Biomonitoring of exposure to nitrous oxide, sevoflurane, isoflurane and halothane by automated GC/MS headspace urinalysis

Occupational exposure of cashiers to Bisphenol A via thermal paper: urinary biomonitoring study

Comparison of urinary thallium levels in non-occupationally exposed people and workers

Biomonitoring of two types of chromium exposure in an electroplating shop

Reference values for cobalt, copper, manganese, and nickel in urine among women of the general population in Japan

Reproductive toxicology in occupational settings: an update

Urinary creatinine concentrations in an industrial workforce and comparison with reference values of the general population