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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zei, Daniela Pascarella, Antonia Barrese, Chiara Pantalone, Simona Stefanini, Stefania |
| Copyright Year | 2009 |
| Abstract | Di-(2-ethylhexyl)-phthalate (DEHP), employed in polyvinyl chloride fabrication and released by endotracheal tubes, is known to cause alterations to several mammalian tissues, markedly in immature animals. The high incidence and severity of bronchopulmonary dysplasia and retinopathy in preterm babies submitted to endotracheal intubation prompted us to investigate the effects of DEHP in lung and retina perinatal development. We previously demonstrated that in rats delivered and breast-fed by DEHP-treated mothers lung alveolarisation is severely impaired. In the present research, the maturation of retinal vessels was studied in (a) flat-mounted retinas obtained after intracardiac injection of FITC-conjugated dextran, (b) flat-mounted retinas incubated with FITC-conjugated Bandeira simplicifolia isolectin B4, marker of vascular endothelial cells, and (c) eyecup sections incubated with biotinylated IB4 and revealed by ABC. DEHP-induced vascular alterations mainly affected the superficial plexus, where the radial vessels showed non-perfused as well as remarkably dilated and branched segments, capillary net appeared coarsely arranged and locally absent; periarteriolar capillary-free regions were still found in 14-day-old animals. This extensive vascular remodelling and generally the high responsiveness to DEHP shown by the immature rat retina confirm previous hypothesis that the phthalate released by PVC medical devices remarkably affects perinatal development of several tissues in different body districts. |
| Starting Page | 567 |
| Ending Page | 575 |
| Page Count | 9 |
| File Format | |
| ISSN | 09486143 |
| Journal | Histochemistry and Cell Biology |
| Volume Number | 132 |
| Issue Number | 5 |
| e-ISSN | 1432119X |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2009-08-23 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Plasticiser Perinatal treatment Retinal fluorangiography IB4 labelling Morphometry Medicine/Public Health Anatomy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Histology Molecular Biology Medical Laboratory Technology |
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