NDLI: Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity

Content Provider	Springer Nature Link
Author	Sandvig, Kirsten Torgersen, Maria Lyngaas Raa, Hilde Andersen Deurs, Bo
Copyright Year	2008
Abstract	Today it is generally accepted that there are several endocytic mechanisms, both the clathrin-dependent one and mechanisms which operate without clathrin and with different requirements when it comes to dynamin, small GTP-binding proteins of the Rho family and specific lipids. It should be noted that clathrin-independent endocytosis can occur even when the cholesterol level in the membrane has been reduced to so low levels that caveolae are gone and clathrin-coated membrane areas are flat. Although new investigators in the field take it for granted that there is a multitude of entry mechanisms, it has taken a long time for this to become accepted. However, more work needs to be done, because one can still ask the question: How many endocytic mechanisms does a cell have, what are their function, and how are they regulated? This article describes some of the history of endocytosis research and attempts to give an overview of the complexity of the mechanisms and their regulation.
Starting Page	267
Ending Page	276
Page Count	10
File Format	PDF
ISSN	09486143
Journal	Histochemistry and Cell Biology
Volume Number	129
Issue Number	3
e-ISSN	1432119X
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-01-12
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Endocytosis Rho proteins Caveolae Flotillin Ricin Shiga toxin Cholera toxin Medicine/Public Health Anatomy
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Molecular Biology Medical Laboratory Technology

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