NDLI: B lymphocyte compartments in the human splenic red pulp: capillary sheaths and periarteriolar regions

Content Provider	Springer Nature Link
Author	Steiniger, Birte S. Seiler, Anja Lampp, Katrin Wilhelmi, Verena Stachniss, Vitus
Copyright Year	2013
Abstract	The microvasculature of human spleens is still incompletely understood. Two enigmatic types of red pulp microvessels, penicillar arterioles and sheathed capillaries, have already been described in the nineteenth century without gaining much attention afterwards. We performed a detailed analysis of sheathed capillaries to clarify the cellular composition of their sheaths by immunohistological double-staining experiments. Capillary sheaths comprise three different cell types, namely specialized cuboidal CD271++ inner sheath cells surrounded by CD271− macrophages and accumulations of B lymphocytes. The CD271++ inner sheath cells express the chemokine CXCL13 in a unique single dot pattern. Sheath-associated B lymphocytes consist of IgM+, IgD++, and of “switched” cells. T lymphocytes do not accumulate in pericapillary sheaths. The predominant sheath-associated macrophage population is CD163−CD68+ and thus differs from the majority of red pulp macrophages. The sheath-associated macrophages strongly express CD169 only in perifollicular sheaths, but not in sheaths located deeper in the red pulp. IgM+, IgD++, and “switched” B cells are also closely associated with red pulp arterioles characterized by the expression of smooth muscle actin in muscle cells and in branched periarteriolar stromal cells. Capillary sheaths are observed in a post-arteriolar position and appear to be of limited length. We suggest to change the term “Vagina periarteriolaris makrophagocytica” of the international histological and embryological terminologies to “Vagina pericapillaris.”
Starting Page	507
Ending Page	518
Page Count	12
File Format	PDF
ISSN	09486143
Journal	Histochemistry and Cell Biology
Volume Number	141
Issue Number	5
e-ISSN	1432119X
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2013-12-17
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human spleen Capillary sheaths Stromal sheath cells CD271 CXCL13 CD169 Biomedicine general Cell Biology Biochemistry Developmental Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Molecular Biology Medical Laboratory Technology

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