NDLI: The spatial and temporal expression of delta-like protein 1 in the rat pituitary gland during development

Content Provider	Springer Nature Link
Author	Nakakura, Takashi Sato, Misa Suzuki, Masakazu Hata, Osamu Takemori, Hiroshi Taniguchi, Yukio Mishima, Yukiri Tanaka, Shigeyasu
Copyright Year	2008
Abstract	An analysis of secreted proteins by the signal sequence trap method using a cDNA library of the rat pituitary anlage at embryonic days (E) 13.5 revealed the abundant expression of delta-like protein 1 (Dlk1) in the pituitary gland. Dlk1, an epidermal growth factor-like repeat protein in preadipocytes, functions in maintaining the preadipose state. Expression of Dlk1 mRNA in the pituitary at E13.5 and in the adult pituitary was confirmed by in situ hybridization. The expression pattern of Dlk1 during pituitary development was also studied by immunohistochemistry. Dlk1 protein first appeared in Rathke’s pouch and the infundibulum at E11.5; as development proceeded, expression became restricted to the pars distalis and pars tuberalis (PT). Dlk1 was expressed in most ACTH cells during the embryonic stages, but its expression was limited to only a few ACTH cells in the adult pituitary. It was also expressed in a small population of TSH, GTH, and PRL cells throughout development, whereas it was present in the cytoplasm of most GH cells at all developmental stages. Similarly, Dlk1 was localized in the cytoplasm of PT cells during development. These findings provide new insights into the mechanism of Dlk1 regarding its regulation of pituitary hormone-secreting cells during development.
Starting Page	141
Ending Page	153
Page Count	13
File Format	PDF
ISSN	09486143
Journal	Histochemistry and Cell Biology
Volume Number	131
Issue Number	1
e-ISSN	1432119X
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-08-27
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Signal sequence trap method Delta-like protein 1 (Dlk1) Pituitary gland Development In situ hybridization Immunohistochemistry Rat (Wistar) Medicine/Public Health Anatomy
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Molecular Biology Medical Laboratory Technology

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