NDLI: Identification of genes specific to “oval cells” in the rat 2-acetylaminofluorene/partial hepatectomy model

Please wait, while we are loading the content...

Developmental appearance of dentin matrix protein 1 during the early dentinogenesis in rat molars as identified by high-resolution immunocytochemistry

Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molar

JNK/ERK–AP-1/Runx2 induction “paves the way” to cartilage load-ignited chondroblastic differentiation

Comparative spatial and temporal localisation of perlecan, aggrecan and type I, II and IV collagen in the ovine meniscus: an ageing study

Programmed cell death and cell extrusion in rat duodenum: a study of expression and activation of caspase-3 in relation to C-jun phosphorylation, DNA fragmentation and apoptotic morphology

Identification of genes specific to “oval cells” in the rat 2-acetylaminofluorene/partial hepatectomy model

Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation

Subcellular characterization of the primordial germ cell antigen PG2 in adult oocytes

Immunolocalization of sex hormone-binding globulin (SHBG) in human ovarian follicles and corpus luteum

Antagonic effects of oestradiol in interaction with IGF-1 on proliferation of lactotroph cells in vitro

Immunohistochemical study of a membrane skeletal molecule, protein 4.1G, in mouse seminiferous tubules

Catecholamine-synthesizing enzymes in the adult and prenatal human testis

Structure and microtubule-nucleation activity of isolated Drosophila embryo centrosomes characterized by whole mount scanning and transmission electron microscopy

A new technique for the quantitative assessment of 8-oxoguanine in nuclear DNA as a marker of oxidative stress. Application to dystrophin-deficient DMD skeletal muscles

Histochemistry and Cell Biology : Volume 124, Issue 2, August 2005

Histochemistry and Cell Biology : Volume 124, Issue 1, July 2005

Histochemistry and Cell Biology : Volume 123

Histochemistry and Cell Biology : Volume 122

Histochemistry and Cell Biology : Volume 121

Histochemistry and Cell Biology : Volume 120

Histochemistry and Cell Biology : Volume 119

Histochemistry and Cell Biology : Volume 118

Histochemistry and Cell Biology : Volume 117

Histochemistry and Cell Biology : Volume 116

Histochemistry and Cell Biology : Volume 115

Histochemistry and Cell Biology : Volume 114

Histochemistry and Cell Biology : Volume 113

Histochemistry and Cell Biology : Volume 112

Histochemistry and Cell Biology : Volume 111

Histochemistry and Cell Biology : Volume 110

Histochemistry and Cell Biology : Volume 109

Histochemistry and Cell Biology : Volume 108

Histochemistry and Cell Biology : Volume 107

Identification of genes specific to “oval cells” in the rat 2-acetylaminofluorene/partial hepatectomy model

Content Provider	Springer Nature Link
Author	Batusic, Danko S. Cimica, Velasco Chen, Yonglong Tron, Kyrylo Hollemann, Thomas Pieler, Tomas Ramadori, Giulia
Copyright Year	2005
Abstract	Under certain conditions liver regeneration can be accomplished by hepatic progenitor cells (“oval cells”). So far, only few factors have been identified to be uniquely regulated by the “oval cell” compartment. Using macroarray analysis in a rat model of oval cell proliferation (treatment with 2-acetylaminofluorene and partial hepatectomy, AAF + PH), we identified 12 differentially expressed genes compared to appropriate control models (AAF treatment and sham operation or AAF treatment alone). Further analysis in models of normal liver regeneration (ordinary PH) and acute phase response (turpentine oil-treated rats) revealed that three out of 12 genes (thymidine kinase 1, Jun-D and ADP-ribosylation factor 4) were not affected by the hepatic acute phase reaction but similarly overexpressed in both “oval cell”-dependant and normal liver regeneration. We characterized Jun-D and ADP-ribosylation factors as novel factors upregulated in oval cells and in non-parenchymal liver cells of normally regenerating livers. However, two out of 12 differentially expressed genes were specifically expressed in oval cells: ras-related protein Rab-3b and Ear-2. On protein level, Rab-3b was increased in total liver homogenates and demonstrated only in clusters of oval cells. We postulate that Ear-2 and Rab-3b may represent novel regulatory factors specifically activated in “oval cells”.
Starting Page	245
Ending Page	260
Page Count	16
File Format	PDF
ISSN	09486143
Journal	Histochemistry and Cell Biology
Volume Number	124
Issue Number	3
e-ISSN	1432119X
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-07-26
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hepatic progenitor cells Liver regeneration Acute phase response Turpentine oil Gene expression profiling Medicine/Public Health Anatomy
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology Molecular Biology Medical Laboratory Technology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Different physiology of interferon-α/-γ in models of liver regeneration in the rat

Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regeneration

Native and Activated Hepatic Stellate Cells Stimulate Liver Regeneration in Rats After Partial Hepatectomy and 2-Acetylaminofluorene Injection

I serial analysis of gene expression of rat liver regeneration by oval hepatic stem cells.

Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes

Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats.

Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Regeneration- and Liver-Specific Genes in a Rat Model of Partial Hepatectomy

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response

Acute hepatic failure-derived bone marrow mesenchymal stem cells express hepatic progenitor cell genes.

Identification of genes specific to “oval cells” in the rat 2-acetylaminofluorene/partial hepatectomy model

Similar Documents

Different physiology of interferon-α/-γ in models of liver regeneration in the rat

Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regeneration

Native and Activated Hepatic Stellate Cells Stimulate Liver Regeneration in Rats After Partial Hepatectomy and 2-Acetylaminofluorene Injection

I serial analysis of gene expression of rat liver regeneration by oval hepatic stem cells.

Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes

Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats.

Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Regeneration- and Liver-Specific Genes in a Rat Model of Partial Hepatectomy

Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response

Acute hepatic failure-derived bone marrow mesenchymal stem cells express hepatic progenitor cell genes.

Identification of genes specific to “oval cells” in the rat 2-acetylaminofluorene/partial hepatectomy model