NDLI: Resetting a functional G1 nucleus after mitosis

Content Provider	Springer Nature Link
Author	de Castro, Ines J. Gokhan, Ezgi Vagnarelli, Paola
Copyright Year	2015
Abstract	The maintenance of the correct cellular information goes beyond the simple transmission of an intact genetic code from one generation to the next. Epigenetic changes, topological cues and correct protein-protein interactions need to be re-established after each cell division to allow the next cell cycle to resume in the correct regulated manner. This process begins with mitotic exit and re-sets all the changes that occurred during mitosis thus restoring a functional G1 nucleus in preparation for the next cell cycle. Mitotic exit is triggered by inactivation of mitotic kinases and the reversal of their phosphorylation activities on many cellular components, from nuclear lamina to transcription factors and chromatin itself. To reverse all these phosphorylations, phosphatases act during mitotic exit in a timely and spatially controlled manner directing the events that lead to a functional G1 nucleus. In this review, we will summarise the recent developments on the control of phosphatases and their known substrates during mitotic exit, and the key steps that control the restoration of chromatin status, nuclear envelope reassembly and nuclear body re-organisation. Although pivotal work has been conducted in this area in yeast, due to differences between the mitotic exit network between yeast and vertebrates, we will mainly concentrate on the vertebrate system.
Starting Page	607
Ending Page	619
Page Count	13
File Format	PDF
ISSN	00095915
Journal	Chromosoma
Volume Number	125
Issue Number	4
e-ISSN	14320886
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2016-01-04
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Phosphatases Mitotic exit Chromatin Nuclear envelope Cell division Cell Biology Developmental Biology Biochemistry Human Genetics Animal Genetics and Genomics Eukaryotic Microbiology
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Late mitotic functions of Aurora kinases

Building a nuclear envelope at the end of mitosis: coordinating membrane reorganization, nuclear pore complex assembly, and chromatin de-condensation

The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin

Dephosphorylation in nuclear reassembly after mitosis

Resetting a functional G1 nucleus after mitosis

Nuclear envelope-limited chromatin sheets (ELCS) and heterochromatin higher order structure

Differential nuclear envelope assembly at the end of mitosis in suspension-cultured Apium graveolens cells

Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint

Chromatin remodeling by nuclear receptors

Resetting a functional G1 nucleus after mitosis

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