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The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila

A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation

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Erratum to: The large noncoding hsrω-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila

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A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation

Content Provider	Springer Nature Link
Author	Al Nadaf, Shafagh Deakin, Janine E. Gilbert, Clément Robinson, Terence J. Graves, Jennifer A. M. Waters, Paul D.
Copyright Year	2011
Abstract	Sex chromosome dosage compensation in both eutherian and marsupial mammals is achieved by X chromosome inactivation (XCI)—transcriptional repression that silences one of the two X chromosomes in the somatic cells of females. We recently used RNA fluorescent in situ hybridization (FISH) to show, in individual nuclei, that marsupial X inactivation (in the absence of XIST) occurs on a gene-by-gene basis, and that escape from inactivation is stochastic and independent of gene location. In the absence of similar data from fibroblast cell lines of eutherian representatives, a meaningful comparison is lacking. We therefore used RNA-FISH to examine XCI in fibroblast cell lines obtained from three distantly related eutherian model species: African savannah elephant (Loxodonta africana), mouse (Mus musculus) and human (Homo sapiens). We show that, unlike the orthologous marsupial X, inactivation of the X conserved region (XCR) in eutherians generally is complete. Two-colour RNA-FISH on female human, mouse and elephant interphase nuclei showed that XCR loci have monoallelic expression in almost all nuclei. However, we found that many loci located in the evolutionarily distinct recently added region (XAR) displayed reproducible locus-specific frequencies of nuclei with either one or two active X alleles. We propose that marsupial XCI retains features of an ancient incomplete silencing mechanism that was augmented by the evolution of the XIST gene that progressively stabilized the eutherian XCR. In contrast, the recently added region of the eutherian X displays an incomplete inactivation profile similar to that observed on the evolutionarily distinct marsupial X and the independently evolved monotreme X chromosomes.
Starting Page	71
Ending Page	78
Page Count	8
File Format	PDF
ISSN	00095915
Journal	Chromosoma
Volume Number	121
Issue Number	1
e-ISSN	14320886
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-09-27
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell Biology Eukaryotic Microbiology Human Genetics Biochemistry Developmental Biology Animal Genetics and Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation

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A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation

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