NDLI: Ionizing radiation effects on the secretory-stage ameloblasts and enamel organic extracellular matrix

Content Provider	Springer Nature Link
Author	Moraes Ramos Perez, Flávia Maria Espírito Santo, Alexandre Ribeiro Cruz Perez, Danyel Elias vaes, Pedro Duarte Bóscolo, Frab rberto Line, Sérgio Roberto Peres Almeida, Solange Maria
Copyright Year	2014
Abstract	This study assessed the effects of high doses of ionizing radiation on eruption rate, odontogenic region morphology, secretory-stage ameloblasts, and enamel organic extracellular matrix (EOECM) of rat maxillary incisors. For the study, 30 male rats were divided into three experimental groups: control (non-irradiated), irradiated by 15 Gy, and irradiated by 25 Gy. Irradiated groups received a single dose of 15 or 25 Gy of X-rays in the head and neck region. The maxillary incisor eruption rate was measured. Sections of 5-µm thickness of the maxillary incisor odontogenic regions were evaluated using bright field light microscopy. Ultrathin sections of secretory ameloblasts and their EOECM were analyzed by transmission electron microscopy (TEM). Irradiated groups showed significantly diminished eruption rate values at the 4th and at the 6th day after irradiation. Reduced optical retardation values were observed in the irradiated groups. The odontogenic region of maxillary incisors from irradiated rats exhibited altered and poorly organized preameloblasts. TEM showed degeneration areas in the secretory-stage EOECM and several autophagosomes in the secretory ameloblasts from irradiated animals. In conclusion, high radiation doses delay eruption and induce disturbances in secretory ameloblasts and EOECM of rat maxillary incisors. These findings may be associated with structural defects of mature enamel.
Starting Page	589
Ending Page	598
Page Count	10
File Format	PDF
ISSN	0301634X
Journal	Radiation and Environmental Biophysics
Volume Number	53
Issue Number	3
e-ISSN	14322099
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2014-04-04
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Amelogenesis Birefringence Dental enamel Radiation therapy Ultrastructure Biophysics and Biological Physics Effects of Radiation/Radiation Protection Environmental Physics Environmental Monitoring/Analysis Ecosystems
Content Type	Text
Resource Type	Article
Subject	Biophysics Environmental Science Radiation

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