NDLI: Mutation induction by inhaled radon progeny modeled at the tissue level

Content Provider	Springer Nature Link
Author	Madas, Balázs G. Balásházy, Imre
Copyright Year	2011
Abstract	The observable responses of living systems to ionizing radiation depend on the level of biological organization studied. Understanding the relationships between the responses characteristic of the different levels of organization is of crucial importance. The main objective of the present study is to investigate how some cellular effects of radiation manifest at the tissue level by modeling mutation induction due to chronic exposure to inhaled radon progeny. For this purpose, a mathematical model of the bronchial epithelium was elaborated to quantify cell nucleus hits and cell doses. Mutagenesis was modeled considering endogenous as well as radiation-induced DNA damages and cell cycle shortening due to cell inactivation. The model parameters describing the cellular effects of radiation are obtained from experimental data. Cell nucleus hits, cell doses, and mutation induction were computed for the activity hot spots of the large bronchi at different exposures. Results demonstrate that the mutagenic effect of densely ionizing radiation is dominated by cell cycle shortening due to cell inactivation and not by DNA damages. This suggests that radiation burdens of non-progenitor cells play a significant role in mutagenesis in case of protracted exposures to densely ionizing radiation. Mutation rate as a function of dose rate exhibits a convex shape below a threshold. This threshold indicates the exhaustion of the tissue regeneration capacity of local progenitor cells. It is suggested that progenitor cell hyperplasia occurs beyond the threshold dose rate, giving a possible explanation of the inverse dose-rate effect observed in the epidemiology of lung cancer among uranium miners.
Starting Page	553
Ending Page	570
Page Count	18
File Format	PDF
ISSN	0301634X
Journal	Radiation and Environmental Biophysics
Volume Number	50
Issue Number	4
e-ISSN	14322099
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-09-06
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Environmental Physics Effects of Radiation/Radiation Protection Environmental Monitoring/Analysis Ecosystems Biophysics and Biological Physics
Content Type	Text
Resource Type	Article
Subject	Biophysics Environmental Science Radiation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Erratum to: Mutation induction by inhaled radon progeny modeled at the tissue level

Lung dosimetry of inhaled radon progeny in mice

Stochastic rat lung dosimetry for inhaled radon progeny: a surrogate for the human lung for lung cancer risk assessment

Deposition of radon progeny on skin surfaces and resulting radiation doses in radon therapy

Assessment of radon equilibrium factor from distribution parameters of simultaneous radon and radon progeny measurements

Doses from radon progeny as a source of external beta and gamma radiation

Impact of haze-fog days to radon progeny equilibrium factor and discussion of related factors

Effect of site-specific bronchial radon progeny deposition on the spatial and temporal distributions of cellular responses

Characteristics of thoron and thoron progeny in Canadian homes

Mutation induction by inhaled radon progeny modeled at the tissue level

Similar Documents

Erratum to: Mutation induction by inhaled radon progeny modeled at the tissue level

Lung dosimetry of inhaled radon progeny in mice

Stochastic rat lung dosimetry for inhaled radon progeny: a surrogate for the human lung for lung cancer risk assessment

Deposition of radon progeny on skin surfaces and resulting radiation doses in radon therapy

Assessment of radon equilibrium factor from distribution parameters of simultaneous radon and radon progeny measurements

Doses from radon progeny as a source of external beta and gamma radiation

Impact of haze-fog days to radon progeny equilibrium factor and discussion of related factors

Effect of site-specific bronchial radon progeny deposition on the spatial and temporal distributions of cellular responses

Characteristics of thoron and thoron progeny in Canadian homes

Mutation induction by inhaled radon progeny modeled at the tissue level