NDLI: Application of the network model for studying the delivery of colloidal drugs

Content Provider	Springer Nature Link
Author	Chang, You Im Cheng, Wei You Gu, Chih Yang
Copyright Year	2011
Abstract	From the viewpoint of colloidal transport phenomena, the individual drug particle’s movement through the tumor is studied by using the square network model. The effects of drug concentration, arterial pressure, and interstitial pressure of the tumor on the concentration breakthrough moment of drug particles are investigated by using the Brownian dynamics simulation method. From the simulation results, we find that the present network model and the Brownian dynamics simulation method can successfully analysis the therapeutic ranges achieved by the drug particles in the tumor at different magnitudes of the drug concentration, the inlet blood velocity, the arterial pressures, and the interstitial pressures of the tumor. Because of the high interstitial fluid pressure, the drug particles can only reach the peripheral region and cannot penetrate inside the target tumor efficiently, and the decreased interstitial fluid pressure will lead more drug particles to penetrate inside the tumor.
Starting Page	1479
Ending Page	1492
Page Count	14
File Format	PDF
ISSN	0303402X
Journal	Colloid and Polymer Science
Volume Number	289
Issue Number	13
e-ISSN	14351536
Language	English
Publisher	Springer-Verlag
Publisher Date	2011-06-28
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Drug delivery Brownian particle Network model Tumor Polymer Sciences Physical Chemistry Soft and Granular Matter, Complex Fluids and Microfluidics Food Science Characterization and Evaluation of Materials
Content Type	Text
Resource Type	Article
Subject	Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics

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