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Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by 1H molecular diffusion NMR and 19F spin diffusion NMR

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Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by 1H molecular diffusion NMR and 19F spin diffusion NMR

Content Provider	Springer Nature Link
Author	Mathias, Errol V. Aponte, Julia Kornfield, Julia A. Ba, Yong
Copyright Year	2010
Abstract	Rf-PEG (fluoroalkyl double-ended poly(ethylene glycol)) hydrogel is potentially useful as a drug delivery depot due to its advanced properties of sol–gel two-phase coexistence and low surface erosion. In this study, 1H molecular diffusion nuclear magnetic resonance (NMR) and 19F spin diffusion NMR were used to probe the drug loading and diffusion properties of the Rf-PEG hydrogel for small anticancer drugs, 5-fluorouracil (FU) and its hydrophobic analog, 1,3-dimethyl-5-fluorouracil (DMFU). It was found that FU has a larger apparent diffusion coefficient than that of DMFU, and the diffusion of the latter was more hindered. The result of 19F spin diffusion NMR for the corresponding freeze-dried samples indicates that a larger portion of DMFU resided in the Rf core/IPDU intermediate-layer region (where IPDU refers to isophorone diurethane, as a linker to interconnect the Rf group and the PEG chain) than that of FU while the opposite is true in the PEG–water phase. To understand the experimental data, a diffusion model was proposed to include: (1) hindered diffusion of the drug molecules in the Rf core/IPDU-intermediate-layer region; (2) relatively free diffusion of the drug molecules in the PEG-water phase (or region); and (3) diffusive exchange of the probe molecules between the above two regions. This study also shows that molecular diffusion NMR combined with spin diffusion NMR is useful in studying the drug loading and diffusion properties in hydrogels for the purpose of drug delivery applications.
Starting Page	1655
Ending Page	1663
Page Count	9
File Format	PDF
ISSN	0303402X
Journal	Colloid and Polymer Science
Volume Number	288
Issue Number	18
e-ISSN	14351536
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-10-05
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fluoroalkyl double-ended poly(ethylene glycol) Hydrogel 5-Fluorouracil 1,3-Dimethyl-5-fluorouracil Dug delivery Molecular diffusion Spin diffusion NMR Food Science Physical Chemistry Characterization and Evaluation of Materials Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences
Content Type	Text
Resource Type	Article
Subject	Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics

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