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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lim, Hyung Jun Lee, Hyunsuk Kim, Keon Hyeong Huh, June Ahn, Cheol Hee Kim, Jin Woong |
| Copyright Year | 2013 |
| Abstract | This study investigated the effect of molecular architecture of amphiphilic star polymers on micelle formation and drug loading and releasing. For this, multi-armed star block copolymers having poly(ethylene glycol) as a hydrophilic block and poly(ε-caprolactone) as a hydrophobic block were synthesized by using a divergent synthetic method consisting of a coupling reaction and a ring opening polymerization. The molecular weight and molecular weight distribution of the block copolymers were characterized by 1H NMR and GPC measurements. Dynamic light scattering and fluorescence spectroscopic analysis were employed to observe micellization, drug loading, and drug release behaviors. We have figured out that the number of arms is a critical factor that changes critical micelle concentration as well as drug loading and releasing behaviors; increase in the number of arms not only led to lowering the critical micelle concentration and drug release rate but also increased the micelle size and drug loading efficiency. |
| Starting Page | 1817 |
| Ending Page | 1827 |
| Page Count | 11 |
| File Format | |
| ISSN | 0303402X |
| Journal | Colloid and Polymer Science |
| Volume Number | 291 |
| Issue Number | 8 |
| e-ISSN | 14351536 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2013-02-05 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Molecular architecture Star polymers Polymeric micelle Drug loading Drug releasing Polymer Sciences Soft and Granular Matter, Complex Fluids and Microfluidics Characterization and Evaluation of Materials Physical Chemistry Food Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics |
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