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| Content Provider | Springer Nature Link |
|---|---|
| Author | Feng, Qiao Li, Fang Yan, Qing Zhi Zhu, Ying Chun Ge, Chang Chun |
| Copyright Year | 2010 |
| Abstract | Thermo-responsive hydrogels of poly(N-isopropylacrylamide) (PNIPAm) were prepared by fontal polymerization and investigated as a temperature-triggered delivery device for the model drug aspirin. The influence of relative amount of reactant components on the feature of the polymerization front was studied. Furthermore, aspirin was loaded into hydrogels prepared by fontal polymerization method and classical polymerization, respectively, and its release characteristics were determined under different temperature conditions (25 °C and 37 °C). The drug storages and kinetic parameters for two hydrogels indicated that drug-loading capacity and drug release of frontal polymerization (FP) hydrogel were improved as compared with the classical polymerization (CP) one. Scanning electronic microscope and differential scanning calorimetry (DSC) results could account for these improvements in drug delivery for FP hydrogel. The above results indicate that FP can be an alternative method for the preparation of PNIPAm hydrogels used as drug delivery devices with less time consuming and easier protocols. |
| Starting Page | 915 |
| Ending Page | 921 |
| Page Count | 7 |
| File Format | |
| ISSN | 0303402X |
| Journal | Colloid and Polymer Science |
| Volume Number | 288 |
| Issue Number | 8 |
| e-ISSN | 14351536 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2010-04-30 |
| Publisher Place | Berlin/Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Frontal polymerization Poly(N-isopropylacrylamide) Hydrogel Thermo-responsive Drug delivery Food Science Physical Chemistry Characterization and Evaluation of Materials Soft and Granular Matter, Complex Fluids and Microfluidics Polymer Sciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics |
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