NDLI: Hyaluronic acid methacrylate derivatives and calcium alginate interpenetrated hydrogel networks for biomedical applications: physico-chemical characterization and protein release

Content Provider	Springer Nature Link
Author	D’Arrigo, Giorgia Di Meo, Chiara Geissler, Erik Coviello, Tommasina Alhaique, Franco Matricardi, Pietro
Copyright Year	2012
Abstract	The preparation of a novel polysaccharide interpenetrating polymer network based on calcium alginate and methacrylated hyaluronic acid is described. The effect of two different solvents, distilled water and 0.9 % (w/v) NaCl, on the matrix formation and on its physico-chemical properties was studied by means of rheological and mechanical measurements. Furthermore, the structural characterization of the hydrogels prepared in the different ionic strength conditions was carried out by small-angle X-ray scattering in order to obtain deeper information useful for the preparation of drug delivery systems. Finally, to evaluate the potential use of the novel matrix as a drug delivery system and, in particular, its suitability for modulated delivery of a bioactive protein, release experiments of horseradish peroxidase, as a model protein, were also carried out.
Starting Page	1575
Ending Page	1582
Page Count	8
File Format	PDF
ISSN	0303402X
Journal	Colloid and Polymer Science
Volume Number	290
Issue Number	15
e-ISSN	14351536
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-07-24
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Calcium alginate Hyaluronic acid Hydrogel IPN Drug delivery Physical Chemistry Characterization and Evaluation of Materials Polymer Sciences Food Science Soft and Granular Matter, Complex Fluids and Microfluidics
Content Type	Text
Resource Type	Article
Subject	Colloid and Surface Chemistry Materials Chemistry Physical and Theoretical Chemistry Polymers and Plastics

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