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| Content Provider | Springer Nature Link |
|---|---|
| Author | Södergren, E. Cederberg, J. Vessby, B. Basu, S. |
| Copyright Year | 2001 |
| Abstract | Background and aims Lipid peroxidation is believed to be involved in the pathophysiology of a number of diseases and in the process of aging. This study investigates the effects of dietary supplementation with vitamin E (20 g/kg diet of all-rac-α-tocopheryl succinate for 3 weeks) on both non-enzymatic and enzymatic lipid peroxidation in experimental rats with carbon tetrachloride (CCl4)-induced hepatotoxicity (2.5 mL/kg body). Methods Plasma, urine and liver samples from control rats (n = 6), CCl4-treated rats (n = 6), and rats supplemented with vitamin E prior to CCl4 treatment (n = 8) were collected. Non-enzymatic lipid peroxidation induced by free radicals was investigated by measurement of a major F2-iso-prostane, 8-iso-prostaglandin F2α (8-iso-PGF2α). Cyclooxygenase-catalyzed enzymatic lipid peroxidation was measured with a major PGF2α metabolite, 15-kto-13,14-dihydro-prostaglandin F2α (15-K-DH-PGF2α). Malondialdehyde and antioxidants in plasma were also quantified. Results CCl4 treatment alone resulted in significantly higher levels of plasma, urinary and liver 8-iso-PGF2α, and of plasma and urinary 15-K-DH-PGF2α compared to controls. Rats supplemented with vitamin E prior to CCl4 treatment had significantly lower levels of urinary and liver 8-iso-PGF2α, urinary 15-K-DH-PGF2α, and plasma malondialdehyde than rats treated with CCl4 alone. However, plasma 8-iso-PGF2α and plasma 15-K-DH-PGF2α were not affected by vitamin E supplementation. Conclusion Thus, both non-enzymatic and enzymatic lipid peroxidation during experimental hepatic oxidative injury were suppressed by dietary vitamin E supplementation in rats. |
| Starting Page | 10 |
| Ending Page | 16 |
| Page Count | 7 |
| File Format | |
| ISSN | 14366207 |
| Journal | European Journal of Nutrition |
| Volume Number | 40 |
| Issue Number | 1 |
| e-ISSN | 14366215 |
| Language | English |
| Publisher | Steinkopff-Verlag |
| Publisher Date | 2001-03-01 |
| Publisher Place | Darmstadt |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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