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| Content Provider | Springer Nature Link |
|---|---|
| Author | Schlörmann, Wiebke Hiller, Beate Jahns, Franziska Zöger, Romy Hennemeier, Isabell Wilhelm, Anne Lindhauer, Meilf G. Glei, Michael |
| Copyright Year | 2011 |
| Abstract | Bread as a staple food product represents an important source for dietary fibre consumption. Effects of wheat bread, wholemeal wheat bread and wholemeal rye bread on mechanisms which could have impact on chemoprevention were analysed in colon cells after in vitro fermentation.Effects of fermented bread samples on gene expression, glutathione S-transferase activity and glutathione content, differentiation, growth and apoptosis were investigated using the human colon adenoma cell line LT97. Additionally, apoptosis was studied in normal and tumour colon tissue by determination of caspase activities.The expression of 76 genes (biotransformation, differentiation, apoptosis) was significantly upregulated (1.5-fold) in LT97 cells. The fermented bread samples were able to significantly increase glutathione S-transferase activity (1.8-fold) and glutathione content (1.4-fold) of the cells. Alkaline phosphatase activity as a marker of differentiation was also significantly enhanced (1.7-fold). The fermented bread samples significantly inhibited LT97 cell growth and increased the level of apoptotic cells (1.8-fold). Only marginal effects on apoptosis in tumour compared to normal tissue were observed.This is the first study which presents chemopreventive effects of different breads after in vitro fermentation. In spite of differences in composition, the results were comparable between the bread types. Nevertheless, they indicate a potential involvement of this staple food product regarding the prevention of colon cancer. |
| Starting Page | 827 |
| Ending Page | 839 |
| Page Count | 13 |
| File Format | |
| ISSN | 14366207 |
| Journal | European Journal of Nutrition |
| Volume Number | 51 |
| Issue Number | 7 |
| e-ISSN | 14366215 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2011-10-28 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Apoptosis Bread Colon cancer Dietary fibre In vitro fermentation Nutrition |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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