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| Content Provider | Springer Nature Link |
|---|---|
| Author | Kotova, Natalia Frostne, Cecilia Abramsson Zetterberg, Lilianne Tareke, Eden Bergman, Rolf Haghdoost, Siamak Paulsson, Birgit Törnqvist, Margareta Segerbäck, Dan Jenssen, Dag Grawé, Jan |
| Copyright Year | 2014 |
| Abstract | Nutrients and food constituents can prevent or contribute to genotoxicity. In this study, the possible influence of a vegetarian/non-vegetarian diet on genotoxic effects was investigated in 58 non-smoking healthy vegetarians (V) and non-vegetarians (NV), age 21–37 years from the Stockholm area in Sweden.Physical activity and dietary habits were similar in both groups, with the exception of the intake of meat and fish. Using flow cytometry, we determined the formation of micronuclei (MN) in transferrin-positive immature peripheral blood reticulocytes (Trf-Ret) (Total: n = 53; V: n = 27; NV: n = 26). Dietary exposure to acrylamide was measured through hemoglobin (Hb) adducts in peripheral erythrocytes (Total: n = 53; V: n = 29; NV: n = 24). Hb adducts of both acrylamide and its genotoxic metabolite glycidamide were monitored as a measure of the corresponding in vivo doses.Our data demonstrated that compared with the non-vegetarians, the vegetarians exhibited lower frequencies of MN (fMN) in the Trf-Ret (p < 0.01, Student’s t test). A multivariate analysis demonstrated that there was no association between the fMN and factors such as age, sex, intake of vitamins/minerals, serum folic acid and vitamin B12 levels, physical activity, and body mass index. The mean Hb adduct levels of acrylamide and glycidamide showed no significant differences between vegetarians and non-vegetarians. Furthermore, there were no significant relationships between the adduct levels and fMN in the individuals. The ratio of the Hb adduct levels from glycidamide and acrylamide, however, showed a significant difference (p < 0.04) between the two groups.These data suggest that the vegetarian diet might be beneficial in lowering genomic instability in healthy individuals. The measured Hb adduct levels indicate that the total intake of acrylamide does not differ between the two studied groups and does not contribute to the observed difference in fMN, although an influence of the diet on the metabolic rates of acrylamide was indicated. In addition, the observed significant difference in the background fMN in the two groups demonstrated that the MN analysis method has a sensitivity applicable to the biomonitoring of human lifestyle factors. |
| Starting Page | 1181 |
| Ending Page | 1190 |
| Page Count | 10 |
| File Format | |
| ISSN | 14366207 |
| Journal | European Journal of Nutrition |
| Volume Number | 54 |
| Issue Number | 7 |
| e-ISSN | 14366215 |
| Language | English |
| Publisher | Springer Berlin Heidelberg |
| Publisher Date | 2014-11-16 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Vegetarian Non-vegetarian Biomonitoring Micronuclei Hemoglobin adducts Nutrition |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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