NDLI: The nutritional control of ghrelin secretion in humans : The effects of enteral vs. parenteral nutrition

Content Provider	Springer Nature Link
Author	Prodam, Flavia Me, Elisa Riganti, Fabrizio Gramaglia, Elena Bellone, Simonetta Baldelli, Roberto Rapa, Anna Lely, Aart Jan Bona, Gianni Ghigo, Ezio Broglio, Fabio
Copyright Year	2006
Abstract	The nutritional control of ghrelin has not been fully clarified yet. Particularly, the influence of aminoacids and lipids is controversial and, moreover, whether the intraluminal gastric contact with nutrients is required or if the modulatory action of nutrients on ghrelin secretion is mediated by insulin is still matter of debate.To clarify the role of nutrients in the control of ghrelin secretion evaluating the effects of intravenous and oral lipids and aminoacids compared with glucose and fructose load in healthy subjects.A total of 6 healthy overnight-fasted volunteers underwent the following testing sessions: (a) iv arginine (ARG, 0.5 g/kg); (b) oral protein load (PRO, 50 g); (c) iv lipid-heparin infusion (Li He, Intralipid 10% 250 ml); (d) oral fat load (OIL, soy oil 40 g); (e) oral glucose load (OGL, 100 g); (f) oral fructose load (OFL, 100 g); (g) iv saline (SAL, 3 ml); (h) oral water load (WL, 200 ml). Total ghrelin, insulin, and glucose were assayed every 15 min from 0 up to +180 min.WL and SAL did not modify insulin, glucose and ghrelin. ARG induced a prompt but transient increase (P < 0.05) of insulin and glucose (P < 0.01), without modifying ghrelin secretion. PRO induced a mild but sustained increase of insulin secretion (P < 0.05) without affecting glucose and ghrelin. Li-He progressively increased circulating glucose (P < 0.01) without modifying insulin and ghrelin secretion. No significant variations in circulating glucose, insulin, and ghrelin occurred after OIL. OGL significantly (P < 0.01) increased insulin and glucose levels and progressively decreased (P < 0.05) ghrelin levels. OFL induced a mild (P < 0.05) increase of insulin without modifying glucose levels. Similarly, OFL was followed by a milder decrease (P < 0.05) of ghrelin levels.Differently from carbohydrates and independently from their modulatory effect on insulin secretion and glucose levels, both lipids and aminoacids play a negligible role in the acute control of ghrelin secretion either after acute enteral and parenteral administration.
Starting Page	399
Ending Page	405
Page Count	7
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	45
Issue Number	7
e-ISSN	14366215
Language	English
Publisher	Steinkopff-Verlag
Publisher Date	2006-09-07
Publisher Place	Darmstadt
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	ghrelin aminoacids lipids enteral nutrition parenteral nutrition Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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