NDLI: The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites

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European Journal of Nutrition : Volume 45, Issue 1, February 2006

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The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites

Content Provider	Springer Nature Link
Author	Silberberg, M. Morand, C. Mathevon, T. Besson, C. Manach, C. Scalbert, A. Remesy, C.
Copyright Year	2005
Abstract	After ingestion of a complex meal containing foods and beverages of plant origin, different polyphenols are likely to be simultaneously present in the intestine. However, almost nothing is known about their interactions and possible consequences on their bioavailability.The present study deals with the intestinal absorption and splanchnic metabolism of three polyphenols, genistein, hesperetin and ferulic acid (FA),when perfused in the small intestine alone or in combination, at different doses (15 and 120 µM).The fate of polyphenols in the small intestine was studied using a rat in situ intestinal perfusion model. Polyphenols were analysed in perfusate, bile and plasma by HPLC. Whatever the perfused dose, the efficiency of the net transfer towards the enterocyte was similar for the three polyphenols and not significantly modified by any association between these molecules. However, FA largely differed from the two flavonoids by its low intestinal secretion of conjugates. When perfused at 15 µM, the secretion of conjugates back to the lumen represented 6.2% of the net transfer into the enterocytes for FA compared to 25.5 and 20 % for genistein and hesperetin respectively. Intestinal conjugation and secretion of conjugates back to the gut lumen varied with the dose of flavonoids: saturation of conjugation was observed for the highest dose or when a high dose of a second flavonoid was perfused simultaneously. Intensity of the biliary secretion substantially differed among tested polyphenols: 7.7% of the net transfer for FA vs 50% for genistein or hesperetin. The extent of the enterohepatic cycling of these polyphenols was proportional to the perfused dose and unaffected by the simultaneous presence of different compounds in the intestine.Genistein and hesperetin appeared less available than FA for peripheral tissues because of a high intestinal and biliary secretion of their conjugates. Moreover, data suggest that a high polyphenol intake may improve their bioavailability due to saturation of the intestinal secretion of conjugates.
Starting Page	88
Ending Page	96
Page Count	9
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	45
Issue Number	2
e-ISSN	14366215
Language	English
Publisher	Steinkopff-Verlag
Publisher Date	2005-06-30
Publisher Place	Darmstadt
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	rats polyphenols in situ perfusion intestinal metabolism biliary secretion Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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