NDLI: Relationship between diet and anticoagulant response to warfarin : A factor analysis

Content Provider	Springer Nature Link
Author	Custódio das Dôres, Silvia Maria Booth, Sarah L. Aújo Martini, Ligia Carvalho Gouvêa, Victor Hugo Padovani, Carlos Roberto Abreu Maffei, Francisco Humberto Campana, Álvaro Oscar Rupp de Paiva, Sérgio Alberto
Copyright Year	2007
Abstract	Diet composition is one of the factors that may contribute to intraindividual variability in the anticoagulant response to warfarin.To determine the associations between food pattern and anticoagulant response to warfarin in a group of Brazilian patients with vascular disease.Recent and usual food intakes were assessed in 115 patients receiving warfarin; and corresponding plasma phylloquinone (vitamin K1), serum triglyceride concentrations, prothrombin time (PT), and International Normalized Ratio (INR) were determined. A factor analysis was used to examine the association of specific foods and biochemical variables with anticoagulant data.Mean age was 59 ± 15 years. Inadequate anticoagulation, defined as values of INR 2 or 3, was found in 48% of the patients. Soybean oil and kidney beans were the primary food sources of phylloquinone intake. Factor analysis yielded four separate factors, explaining 56.4% of the total variance in the data set. The factor analysis revealed that intakes of kidney beans and soybean oil, 24-h recall of phylloquinone intake, PT and INR loaded significantly on factor 1. Triglycerides, PT, INR, plasma phylloquinone, and duration of anticoagulation therapy loaded on factor 3.Fluctuations in phylloquinone intake, particularly from kidney beans, and plasma phylloquinone concentrations were associated with variation in measures of anticoagulation (PT and INR) in a Brazilian group of patients with vascular disease.
Starting Page	147
Ending Page	154
Page Count	8
File Format	PDF
ISSN	14366207
Journal	European Journal of Nutrition
Volume Number	46
Issue Number	3
e-ISSN	14366215
Language	English
Publisher	Steinkopff-Verlag
Publisher Date	2007-03-13
Publisher Place	Darmstadt
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	phylloquinone warfarin oral anticoagulant response kidney beans diet Nutrition
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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