NDLI: Von Willebrand factor is reversibly decreased during torpor in 13-lined ground squirrels

Content Provider	Springer Nature Link
Author	Cooper, Scott Sell, Shawn Nelson, Luke Hawes, Jennifer Benrud, Jacob A. Kohlnhofer, Bridget M. Burmeister, Bradley R. Flood, Veronica H.
Copyright Year	2015
Abstract	During torpor in a hibernating mammal, decreased blood flow increases the risk of blood clots such as deep vein thrombi (DVT). In other animal models platelets, neutrophils, monocytes and von Willebrand factor (VWF) have been found in DVT. Previous research has shown that hibernating mammals decrease their levels of platelets and clotting factors VIII (FVIII) and IX (FIX), increasing both bleeding time and activated partial thromboplastin time. In this study, FVIII, FIX and VWF activities and mRNA levels were measured in torpid and non-hibernating ground squirrels (Ictidomys tridecemlineatus). Here, we show that VWF high molecular weight multimers, collagen-binding activity, lung mRNA and promoter activity decrease during torpor. The VWF multimers reappear in plasma within 2 h of arousal in the spring. Similarly, FIX activity and liver mRNA both dropped threefold during torpor. In contrast, FVIII liver mRNA levels increased twofold while its activity dropped threefold, consistent with a post-transcriptional decrease in FVIII stability in the plasma due to decreased VWF levels. Finally, both neutrophils and monocytes are decreased eightfold during torpor which could slow the formation of DVT. In addition to providing insight in how blood clotting can be regulated to allow mammals to survive in extreme environments, hibernating ground squirrels provide an interesting model for studying.
Starting Page	131
Ending Page	139
Page Count	9
File Format	PDF
ISSN	01741578
Journal	Journal of Comparative Physiology B
Volume Number	186
Issue Number	1
e-ISSN	1432136X
Language	English
Publisher	Springer Berlin Heidelberg
Publisher Date	2015-10-20
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Factor VIII Factor IX Deep vein thrombosis Hibernation Neutrophil DNA NET Animal Physiology Biomedicine general Human Physiology Zoology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Animal Science and Zoology Ecology, Evolution, Behavior and Systematics Endocrinology

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