NDLI: The role of succinate dehydrogenase and oxaloacetate in metabolic suppression during hibernation and arousal

Content Provider	Springer Nature Link
Author	Armstrong, Christopher Staples, James F.
Copyright Year	2010
Abstract	Hibernation elicits a major reduction in whole-animal O2 consumption that corresponds with active suppression of liver mitochondrial electron transport capacity at, or downstream of, succinate dehydrogenase (SDH). During arousal from the torpor phase of hibernation this suppression is reversed and metabolic rates rise dramatically. In this study, we used the 13-lined ground squirrel (Ictidomys tridecemlineatus) to assess isolated liver mitochondrial respiration during the torpor phase of hibernation and various stages of arousal to elucidate a potential role of SDH in metabolic suppression. State 3 and state 4 respiration rates were seven- and threefold lower in torpor compared with the summer-active and interbout euthermic states. Respiration rates increased during arousal so that when body temperature reached 30°C in late arousal, state 3 and state 4 respiration were 3.3- and 1.8-fold greater than during torpor, respectively. SDH activity was 72% higher in interbout euthermia than in torpor. Pre-incubating with isocitrate [to alleviate oxaloacetate (OAA) inhibition] increased state 3 respiration rate during torpor by 91%, but this rate was still fourfold lower than that measured in interbout euthermia. Isocitrate pre-incubation also eliminated differences in SDH activity among hibernation bout stages. OAA concentration correlated negatively with both respiration rates and SDH activity. These data suggest that OAA reversibly inhibits SDH in torpor, but cannot fully account for the drastic metabolic suppression observed during this hibernation phase.
Starting Page	775
Ending Page	783
Page Count	9
File Format	PDF
ISSN	01741578
Journal	Journal of Comparative Physiology B
Volume Number	180
Issue Number	5
e-ISSN	1432136X
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-01-30
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hibernation Arousal Mitochondria Succinate dehydrogenase Oxaloacetate Animal Physiology Biomedicine general Zoology Human Physiology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Animal Science and Zoology Ecology, Evolution, Behavior and Systematics Endocrinology

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