NDLI: Isoflurane blocks glutamatergic excitatory transmission pre- and postsynaptically in crayfish muscle

Content Provider	Springer Nature Link
Author	Schramm, M. Dudel, J.
Copyright Year	1998
Abstract	Crayfish neuromuscular junctions are good models for the α-amino-hydroxy-5-methyl-4-isoxazol-propionic acid-type of vertebrate brain excitatory synapses. The action of a typical volatile anaesthetic, isoflurane, was studied on the excitatory postsynaptic currents recorded with a perfused macropatch electrode. Isoflurane reduced quantal exitatory postsynaptic currents in amplitude, in their rise time and in the decay time constant. Small such effects were elicited by <1 mmol · l−1 isoflurane, while the maximal isoflurane concentration of 7 mmol · l−1 reduced the amplitude to about a quarter and shortened the decay time constant even more, while the rise time was diminished by about a quarter. This combination of effects is typical for an open channel block for which an approximate binding rate constant of isoflurane of 6 · 105 mol−1l · s−1 and an unbinding rate of 10–100 s−1 is derived. In addition to this postsynaptic effect, isoflurane inhibited the release of transmitter quanta from the terminal, for instance with 2.5 mmol · l−1 isoflurane by a factor of 7.3 ± 6.3 (SD). In the glutamatergic nerve terminals release is modulated by low glutamate concentrations via a metabotropic autoreceptor which is blocked by the combination of 6-cyano-7-nitro-quinoxaline-2,3-dione and dl-2-amino-5-phosphor-valeric acid. This blocker combination also can prevent the inhibition of release by isoflurane, and it may be suggested that isoflurane elicits inhibition of release through the metabotropic presynaptic glutamate receptors.
Starting Page	237
Ending Page	246
Page Count	10
File Format	PDF
ISSN	03407594
Journal	Journal of Comparative Physiology A
Volume Number	183
Issue Number	2
e-ISSN	14321351
Language	English
Publisher	Springer-Verlag
Publisher Date	1998-07-23
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Behavioral Neuroscience Animal Science and Zoology Ecology, Evolution, Behavior and Systematics

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