NDLI: Transient and persistent tetrodotoxin-sensitive sodium currents in squid olfactory receptor neurons

Content Provider	Springer Nature Link
Author	Chen, N. Lucero, M. T.
Copyright Year	1999
Abstract	Squid olfactory receptor neurons are primary bipolar sensory neurons capable of transducing water-born odorant signals into electrical impulses that are transmitted to the brain. In this study, we have identified and characterized the macroscopic properties of voltage-gated Na+ channels in olfactory receptor neurons from the squid Lolliguncula brevis. Using whole-cell voltage-clamp techniques, we found that the voltage-gated Na+ channels were tetrodotoxin sensitive and had current densities ranging from 5 to 169 pA pF−1. Analyses of the voltage dependence and kinetics revealed interesting differences from voltage-gated Na+ channels in olfactory receptor neurons from other species; the voltage of half-inactivation was shifted to the right and the voltage of half-activation was shifted to the left such that a “window-current” occurred, where 10–18% of the Na+ channels activated and did not inactivate at potentials near action potential threshold. Our findings suggest that in squid olfactory neurons, a subset of voltage-gated Na+ channels may play a role in generating a pacemaker-type current for setting the tonic levels of electrical activity required for transmission of hyperpolarizing odor responses to the brain.
Starting Page	63
Ending Page	72
Page Count	10
File Format	PDF
ISSN	03407594
Journal	Journal of Comparative Physiology A
Volume Number	184
Issue Number	1
e-ISSN	14321351
Language	English
Publisher	Springer-Verlag
Publisher Date	1999-02-05
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Physiology Behavioral Neuroscience Animal Science and Zoology Ecology, Evolution, Behavior and Systematics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Betaine activates a hyperpolarizing chloride conductance in squid olfactory receptor neurons

Mixture interactions of glutamate and betaine in single squid olfactory neurons

Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis

Functional and molecular evolution of olfactory neurons and receptors for aliphatic esters across the Drosophila genus

Responses of olfactory receptor neurons in Utetheisa ornatrix to gender-specific odors

Sodium-dependent plateau potentials in electrocytes of the electric fish Gymnotus carapo

Host plant volatiles synergize responses of sex pheromone-specific olfactory receptor neurons in male Helicoverpa zea

Mechanisms of chloride uptake in frog olfactory receptor neurons

Spatial organization of olfactory receptor neurons on the antenna of the cabbage looper moth

Transient and persistent tetrodotoxin-sensitive sodium currents in squid olfactory receptor neurons

Similar Documents

Betaine activates a hyperpolarizing chloride conductance in squid olfactory receptor neurons

Mixture interactions of glutamate and betaine in single squid olfactory neurons

Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis

Functional and molecular evolution of olfactory neurons and receptors for aliphatic esters across the Drosophila genus

Responses of olfactory receptor neurons in Utetheisa ornatrix to gender-specific odors

Sodium-dependent plateau potentials in electrocytes of the electric fish Gymnotus carapo

Host plant volatiles synergize responses of sex pheromone-specific olfactory receptor neurons in male Helicoverpa zea

Mechanisms of chloride uptake in frog olfactory receptor neurons

Spatial organization of olfactory receptor neurons on the antenna of the cabbage looper moth

Transient and persistent tetrodotoxin-sensitive sodium currents in squid olfactory receptor neurons