NDLI: Nociceptors: a phylogenetic view

Content Provider	Springer Nature Link
Author	Smith, Ewan St. John Lewin, Gary R.
Copyright Year	2009
Abstract	The ability to react to environmental change is crucial for the survival of an organism and an essential prerequisite is the capacity to detect and respond to aversive stimuli. The importance of having an inbuilt “detect and protect” system is illustrated by the fact that most animals have dedicated sensory afferents which respond to noxious stimuli called nociceptors. Should injury occur there is often sensitization, whereby increased nociceptor sensitivity and/or plasticity of nociceptor-related neural circuits acts as a protection mechanism for the afflicted body part. Studying nociception and nociceptors in different model organisms has demonstrated that there are similarities from invertebrates right through to humans. The development of technology to genetically manipulate organisms, especially mice, has led to an understanding of some of the key molecular players in nociceptor function. This review will focus on what is known about nociceptors throughout the Animalia kingdom and what similarities exist across phyla; especially at the molecular level of ion channels.
Starting Page	1089
Ending Page	1106
Page Count	18
File Format	PDF
ISSN	03407594
Journal	Journal of Comparative Physiology A
Volume Number	195
Issue Number	12
e-ISSN	14321351
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-10-11
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nociception Mechanosensation Pain ASIC TRP Animal Physiology Zoology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Physiology Behavioral Neuroscience Animal Science and Zoology Ecology, Evolution, Behavior and Systematics

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Nociceptors: a phylogenetic view

Nociceptors: a phylogenetic view

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