NDLI: Endocrine modulation of a pheromone-responsive gene in the honey bee brain

Content Provider	Springer Nature Link
Author	Grozinger, Christina M. Robinson, Gene E.
Copyright Year	2006
Abstract	Pheromones cause dramatic changes in behavior and physiology, and are critical for honey bee colony organization. Queen mandibular pheromone (QMP) regulates multiple behaviors in worker bees (Slessor et al. in J Chem Ecol 31(11):2731–2745, 2005). We also identified genes whose brain expression levels were altered by exposure to QMP (Grozinger et al. in Proc Natl Acad Sci USA 100(Suppl 2):14519–14525, 2003). Krüppel-homolog 1 (Kr-h1) RNA levels were significantly downregulated by QMP, and were higher in foragers than in nurses (Whitfield et al. in Science 302(5643):296–299, 2003). Here we report on results of behavioral and pharmacological experiments that characterize factors regulating expression of Kr-h1. Foragers have higher brain levels of Kr-h1 than in-hive bees, regardless of age and pheromone exposure. Furthermore, forager Kr-h1 levels were not affected by QMP. Since the onset of foraging is caused, in part, by increasing juvenile hormone blood titers and brain octopamine levels, we investigated the effects of octopamine and methoprene (a juvenile hormone analog) on Kr-h1 expression. Methoprene produced a marginal (not significant) increase in Kr-h1 expression, but Kr-h1 brain levels in methoprene-treated bees were no longer downregulated by QMP. Octopamine did not modulate Kr-h1 expression. Our results demonstrate that the gene expression response to QMP is not hard-wired in the brain but is instead dependent on worker behavioral state.
Starting Page	461
Ending Page	470
Page Count	10
File Format	PDF
ISSN	03407594
Journal	Journal of Comparative Physiology A
Volume Number	193
Issue Number	4
e-ISSN	14321351
Language	English
Publisher	Springer-Verlag
Publisher Date	2006-12-28
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Apis mellifera Gene expression Juvenile hormone Queen mandibular pheromone Krüppel homolog 1 Zoology Neurosciences Animal Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Behavioral Neuroscience Animal Science and Zoology Ecology, Evolution, Behavior and Systematics

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New insights into honey bee (Apis mellifera) pheromone communication. Is the queen mandibular pheromone alone in colony regulation?

Queen mandibular gland pheromone influences worker honey bee (Apis mellifera L.) foraging ontogeny and juvenile hormone titers.

Influences of octopamine and juvenile hormone on locomotor behavior and period gene expression in the honeybee, Apis mellifera

Queen and young larval pheromones impact nursing and reproductive physiology of honey bee (Apis mellifera) workers

CGMP modulates responses to queen mandibular pheromone in worker honey bees

Neurophysiological mechanisms underlying sex- and maturation-related variation in pheromone responses in honey bees (Apis mellifera)

Effect of age, behaviour and social environment on honey bee brain plasticity

Selective modulation of task performance by octopamine in honey bee (Apis mellifera) division of labour

Reproductive physiology mediates honey bee (Apis mellifera) worker responses to social cues

Endocrine modulation of a pheromone-responsive gene in the honey bee brain

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