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| Content Provider | Springer Nature Link |
|---|---|
| Author | Cheng, Jinping Pi, Shuaishuai Ye, Shufeng Gao, Haomin Yao, Lei Jiang, Zhenyi Song, Yuling Xi, Lei |
| Copyright Year | 2012 |
| Abstract | The current testing for paralytic shellfish poisoning (PSP) in shellfish is based on the mouse bioassay (MBA). To alleviate animal welfare concerns, we evaluated the utility of using sublethal indicators of toxicity as an alternative to measuring time to death. Live mice were injected with a PSP congener and the changes in neurotransmitter levels were measured 60, 90, and 120 min after injection. Acetylcholine (ACh) was the most sensitive marker for PSP toxicity. The changes in neurotransmitter levels were most pronounced in the blood. Thus, measurement of Ach levels in the blood may serve as a sensitive predictor for PSP that would not require sacrifice of the mice. This method was relatively simple, sensitive (less than 1 μg/kg weight, equivalent to 20 ng/mL), low maintenance, and rapid (less than 60 min). |
| Starting Page | 786 |
| Ending Page | 790 |
| Page Count | 5 |
| File Format | |
| ISSN | 02544059 |
| Journal | Chinese Journal of Oceanology and Limnology |
| Volume Number | 30 |
| Issue Number | 5 |
| e-ISSN | 19935005 |
| Language | English |
| Publisher | SP Science Press |
| Publisher Date | 2012-09-05 |
| Publisher Place | Heidelberg |
| Access Restriction | Subscribed |
| Subject Keyword | paralytic shellfish poisoning (PSP) mouse bioassay acetylcholine assay Oceanography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Water Science and Technology Oceanography |
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