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| Content Provider | Springer Nature Link |
|---|---|
| Author | Sun, Hong Gao, Shushan Li, Xiaoming Li, Chunshun Wang, Bingui |
| Copyright Year | 2013 |
| Abstract | A chemical investigation of the ethyl acetate extract of the fermentation broth of Alternaria tenuissima EN-192, an endophytic fungus obtained from the stems of the marine mangrove plant Rhizophora stylosa, resulted in the isolation of nine known secondary metabolites, including four indole-diterpenoids: penijanthine A (1), paspaline (2), paspalinine (3), and penitrem A (4); three tricycloalternarene derivatives: tricycloalternarene 3a (5), tricycloalternarene 1b (6), and tricycloalternarene 2b (7); and two alternariol congeners: djalonensone (8) and alternariol (9). The chemical structures of these metabolites were characterized through a combination of detailed spectroscopic analyses and their comparison with reports from the literature. The inhibitory activities of each isolated compound against four bacteria were evaluated and compounds 5 and 8 displayed moderate activity against the aquaculture pathogenic bacterium Vibrio anguillarum, with inhibition zone diameters of 8 and 9 mm, respectively, at 100 μg/disk. To the best of our knowledge, this is the first report on the secondary metabolites of mangrove-derived A lternaria tenuissima and also the first report of the isolation of indole-diterpenoids from fungal genus A lternaria. |
| Starting Page | 464 |
| Ending Page | 470 |
| Page Count | 7 |
| File Format | |
| ISSN | 02544059 |
| Journal | Chinese Journal of Oceanology and Limnology |
| Volume Number | 31 |
| Issue Number | 2 |
| e-ISSN | 19935005 |
| Language | English |
| Publisher | SP Science Press |
| Publisher Date | 2013-03-07 |
| Publisher Place | Heidelberg |
| Access Restriction | Subscribed |
| Subject Keyword | endophytic fungus Alternaria tenuissima Rhizophora stylosa indole-diterpene Oceanography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Water Science and Technology Oceanography |
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