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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yujiang, Zhang Songmei, Zhan Pengli, Cao Ning, Liu Xuehong, Chen Yuejun, Wang Chunbo, Wang |
| Copyright Year | 2003 |
| Abstract | To investigate the effect of polypeptide fromChlamys farreri (PCF) on NHDFin vitro, we modeled oxidative damage on normal human dermal fibroblasts (NHDF) exposed to ultraviolet B (UVB). In this study, 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) were tested to measure cell viability. Enzymes including superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (CAT) and xanthine oxidase (XOD) were determined biochemically. Total antioxidative capacity (T-AOC) and anti-superoxide anion capacity (A-SAC) were also determined. Ultrastructure of fibroblasts was observed under transmission electron microscope. The results showed that: UVB (1.176×10−4 J/cm2) suppressed the growth of fibroblasts and the introduction of PCF (0.25%–1%) before UVB reduced the suppression in a concentration-dependent manner. PCF could enhance the activities of SOD, GSH-PX and T-AOC as well as A-SAC. Also PCF could inhibit XOD activity, while it did not affect CAT activity. Ultrastructure of fibroblasts were damaged after UVB irradiation, concentration-dependent PCF reduced the destructive effect of UVB on cells. These results indicated that PCF can protect human dermal fibroblasts from being harmed by UVB irradiation via its antioxidant proerty. |
| Starting Page | 357 |
| Ending Page | 362 |
| Page Count | 6 |
| File Format | |
| ISSN | 02544059 |
| Journal | Chinese Journal of Oceanology and Limnology |
| Volume Number | 23 |
| Issue Number | 3 |
| e-ISSN | 19935005 |
| Language | English |
| Publisher | Science Press |
| Publisher Date | 2003-01-01 |
| Publisher Place | Beijing |
| Access Restriction | Subscribed |
| Subject Keyword | polypeptide fromChlamys farreri ultraviolet ray oxygen free radicals antioxidant human dermal fibroblast Oceanography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Water Science and Technology Oceanography |
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