NDLI: Functionally graded PCL/β-TCP biocomposites in a multilayered structure for bone tissue regeneration

Content Provider	Springer Nature Link
Author	Kim, Yong Bok Kim, GeunHyung
Copyright Year	2012
Abstract	Functionally graded (FG) composites consisting of polycaprolactone (PCL) and beta-tricalcium phosphate (β-TCP) particles were fabricated with a multilayered structure using a melt plotter with a two-heating-barrel system. Using this process, the concentration of β-TCP particles varied in each layered strut. Scanning electron microscopy (SEM) and energy dispersive spectroscopy mapping of calcium on the fabricated scaffolds indicated that the β-TCP particles were well distributed in each PCL strut, according to conceptual design. By incorporating β-TCP, the FG-PCL/β-TCP scaffolds had meaningful increases in water absorption (30 % increase) and showed good mechanical properties, although the mechanical properties are slightly low compared to pure PCL/β-TCP composite. We performed biological assessments to evaluate the capability of these FG scaffolds to act as a biomaterial for bone tissue regeneration with osteoblast-like cells (MG63). SEM images of cell-seeded FG scaffolds showed that the concentrated β-TCP struts were affected as good cell attachment/proliferation sites. Additionally, calcium deposition on the FG scaffolds was higher than that of normal scaffolds after 14 days. In particular, we observed high levels of mineralization in the highly concentrated β-TCP struts in the FG scaffolds. Based on these results, we believe that the FG scaffolds having various spatially designed structures with graded properties will be widely applicable for hard tissue engineering applications.
Starting Page	949
Ending Page	959
Page Count	11
File Format	PDF
ISSN	09478396
Journal	Applied Physics A
Volume Number	108
Issue Number	4
e-ISSN	14320630
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-06-03
Publisher Place	Berlin, Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Operating Procedures, Materials Treatment Condensed Matter Physics Surfaces and Interfaces, Thin Films Optical and Electronic Materials Characterization and Evaluation of Materials Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Chemistry Materials Science

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