NDLI: Neurobehavioral mutants identified in an ENU-mutagenesis project

Content Provider	Springer Nature Link
Author	Cook, Melloni N. Dunning, Jonathan P. Wiley, Ronald G. Chesler, Elissa J. Johnson, Dabney K. Miller, Darla R. Goldowitz, Dan
Copyright Year	2007
Abstract	We report on a battery of behavioral screening tests that successfully identified several neurobehavioral mutants among a large-scale ENU-mutagenized mouse population. Large numbers of ENU-mutagenized mice were screened for abnormalities in central nervous system function based on abnormal performance in a series of behavior tasks. We developed and used a high-throughput screen of behavioral tasks to detect behavioral outliers. Twelve mutant pedigrees, representing a broad range of behavioral phenotypes, have been identified. Specifically, we have identified two open-field mutants (one displaying hyperlocomotion, the other hypolocomotion), four tail-suspension mutants (all displaying increased immobility), one nociception mutant (displaying abnormal responsiveness to thermal pain), two prepulse inhibition mutants (displaying poor inhibition of the startle response), one anxiety-related mutant (displaying decreased anxiety in the light/dark test), and one learning-and-memory mutant (displaying reduced response to the conditioned stimulus). These findings highlight the utility of a set of behavioral tasks used in a high-throughput screen to identify neurobehavioral mutants. Further analysis (i.e., behavioral and genetic mapping studies) of mutants is in progress with the ultimate goal of identification of novel genes and mouse models relevant to human disorders as well as the identification of novel therapeutic targets.
Starting Page	559
Ending Page	572
Page Count	14
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	18
Issue Number	8
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	2007-07-15
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zoology Anatomy Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

From ENU mutagenesis to population genetics

The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes

ENU mutagenesis in mice identifies candidate genes for hypogonadism

ENU mutagenesis in zebrafish—from genes to complex diseases

Establishing an ENU mutagenesis screen for the piebald region of mouse Chromosome 14

The large-scale Munich ENU-mouse-mutagenesis screen

Analysis of the MCMV resistome by ENU mutagenesis

The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry

Great times for mouse genetics: getting ready for large-scale ENU-mutagenesis

Neurobehavioral mutants identified in an ENU-mutagenesis project

Similar Documents

From ENU mutagenesis to population genetics

The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes

ENU mutagenesis in mice identifies candidate genes for hypogonadism

ENU mutagenesis in zebrafish—from genes to complex diseases

Establishing an ENU mutagenesis screen for the piebald region of mouse Chromosome 14

The large-scale Munich ENU-mouse-mutagenesis screen

Analysis of the MCMV resistome by ENU mutagenesis

The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry

Great times for mouse genetics: getting ready for large-scale ENU-mutagenesis

Neurobehavioral mutants identified in an ENU-mutagenesis project