NDLI: Genome-wide screening for genetic loci associated with noise-induced hearing loss

Content Provider	Springer Nature Link
Author	White, Cory H. Ohmen, Jeffrey D. Sheth, Sonal Zebboudj, Amina F. McHugh, Richard K. Hoffman, Larry F. Lusis, Aldons J. Davis, Richard C. Friedman, Rick A.
Copyright Year	2009
Abstract	Noise-induced hearing loss (NIHL) is one of the more common sources of environmentally induced hearing loss in adults. In a mouse model, Castaneous (CAST/Ei) is an inbred strain that is resistant to NIHL, while the C57BL/6J strain is susceptible. We have used the genome-tagged mice (GTM) library of congenic strains, carrying defined segments of the CAST/Ei genome introgressed onto the C57BL/6J background, to search for loci modifying the noise-induced damage seen in the C57BL/6J strain. NIHL was induced by exposing 6-8-week old mice to 108 dB SPL intensity noise. We tested the hearing of each mouse strain up to 23 days after noise exposure using auditory brainstem response (ABR). This study identifies a number of genetic loci that modify the initial response to damaging noise, as well as long-term recovery. The data suggest that multiple alleles within the CAST/Ei genome modify the pathogenesis of NIHL and that screening congenic libraries for loci that underlie traits of interest can be easily carried out in a high-throughput fashion.
Starting Page	207
Ending Page	213
Page Count	7
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	20
Issue Number	4
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	2009-04-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zoology Anatomy Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

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