NDLI: Genomic organization and expression profile of the human and mouse WAVE gene family

Please wait, while we are loading the content...

Loci on Chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains

Genomic organization and expression profile of the human and mouse WAVE gene family

Cloning, functional study and comparative mapping of Luzp2 to mouse Chromosome 7 and human Chromosome 11p13–11p14

An autoimmune diabetes locus (Idd21) on mouse Chromosome 18

PepPat, a pattern-based oligopeptide homology search method and the identification of a novel tachykinin-like peptide

Marker-assisted congenic screening (MACS): A database tool for the efficient production and characterization of congenic lines

Erratum

Announcements

Mammalian Genome : Volume 14, Issue 4, April 2003

Mammalian Genome : Volume 14, Issue 3, March 2003

Mammalian Genome : Volume 14, Issue 2, February 2003

Mammalian Genome : Volume 14, Issue 1, January 2003

Mammalian Genome : Volume 13

Mammalian Genome : Volume 12

Mammalian Genome : Volume 11

Mammalian Genome : Volume 10

Mammalian Genome : Volume 9

Mammalian Genome : Volume 8

Mammalian Genome : Volume 7

Genomic organization and expression profile of the human and mouse WAVE gene family

Content Provider	Springer Nature Link
Author	Sossey Alaoui, Khalid Head, Karen wak, rma Cowell, John K.
Copyright Year	2003
Abstract	The WAVE gene family, which contains three members, has been shown to play a major role in the actin polymerization and cytoskeleton organization processes. We have identified the WAVE3 gene from Chromosome (Chr) 13q12, as being involved in one of the breakpoints of a t(1:13)(q21:q12) reciprocal translocation, in a patient with ganglioneuroblastoma (Sossey-Alaoui et al. 2002; Oncogene 21: 5967–5974). We have also reported the cloning of the mouse Wave3. During our analysis of the human gene map, we also noted that WAVE2 maps to Chr region lp35-36, which frequently undergoes loss of heterozygosity and deletion in advanced stage neuroblastoma. These data clearly indicate a possible involvement of the WAVE genes in the pathogenesis of neuroblastoma. In this study, we report the complete genomic organization and expression profile of the three human WAVE genes and their mouse orthologs. We show that the WAVE genes have distinctive expression patterns in both adult and fetal human and mouse tissues. We also show a high level of conservation between these genes, in both the nucleotide and protein sequences. We finally show that the genomic structure is highly conserved among these genes and that the mouse Wave genes map to chromosome regions that have synteny in the human genome. The gene content in these syntenic regions is also conserved, suggesting that the WAVE genes are derived from a common ancient ancestor by genome duplication. The genomic characterization and expression analysis of the WAVE genes provide the basis towards understanding the function of these genes. It also provides the first steps towards the development of mouse models for the role of the WAVE genes in actin and cytoskeleton organization in general, and in the development of neuroblastoma in particular.
Starting Page	314
Ending Page	322
Page Count	9
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	14
Issue Number	5
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-09-02
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Genomic organization and expression of the mouse Brca2 gene

Genomic organization and chromosomal localization of the human casein gene family

Sequence and genomic organization of the mouse Lim1 gene

Genomic organization and expression analysis of the mouse qkI locus

The mouse Kell blood group gene (Kel): cDNA sequence, genomic organization, expression, and enzymatic function

Genomic organization and refined mapping of the mouse β-dystrobrevin gene

Cerd4, third member of the d4 gene family: expression and organization of genomic locus

Genomic organization of the human CD5 gene

Genomic organization and chromosomal localization of the mouse lipopolysaccharide binding protein gene

Genomic organization and expression profile of the human and mouse WAVE gene family

Similar Documents

Genomic organization and expression of the mouse Brca2 gene

Genomic organization and chromosomal localization of the human casein gene family

Sequence and genomic organization of the mouse Lim1 gene

Genomic organization and expression analysis of the mouse qkI locus

The mouse Kell blood group gene (Kel): cDNA sequence, genomic organization, expression, and enzymatic function

Genomic organization and refined mapping of the mouse β-dystrobrevin gene

Cerd4, third member of the d4 gene family: expression and organization of genomic locus

Genomic organization of the human CD5 gene

Genomic organization and chromosomal localization of the mouse lipopolysaccharide binding protein gene

Genomic organization and expression profile of the human and mouse WAVE gene family