NDLI: Genetic factors and diet affect long-bone length in the F34 LG,SM advanced intercross

Content Provider	Springer Nature Link
Author	rgard, Elizabeth A. Lawson, Heather A. Pletscher, L. Susan Wang, Bing Brooks, Victoria R. Wolf, Jason B. Cheverud, James M.
Copyright Year	2010
Abstract	Previous studies on the LG,SM advanced intercross line have identified approximately 40 quantitative trait loci (QTL) for long -bone (humerus, ulna, femur, and tibia) lengths. In this study, long-bone-length QTL were fine-mapped in the F34 generation (n = 1424) of the LG,SM advanced intercross. Environmental effects were assessed by dividing the population by sex between high-fat and low-fat diets, producing eight sex/diet cohorts. We identified 145 individual bone-length QTL comprising 45 pleiotropic QTL; 69 replicated QTL from previous studies, 35 were new traits significant at previously identified loci, and 41 were novel QTL. Many QTL affected only a subset of the population based on sex and/or diet. Eight of ten known skeletal growth genes were upregulated in 3-week-old LG/J male proximal tibial growth plates relative to SM/J.The sequences of parental strains LG/J and SM/J indicated the presence of over half a million polymorphisms in the confidence intervals of these 45 QTL. We examined 526 polymorphisms and found that 97 represented radical changes to amino acid composition while 40 were predicted to be deleterious to protein function.Additional experimentation is required to understand how changes in gene regulation or protein function can alter the genetic architecture and interact with the environment to produce phenotypic variation.
Starting Page	178
Ending Page	196
Page Count	19
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	22
Issue Number	3-4
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	2010-12-19
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Zoology Cell Biology Anatomy
Content Type	Text
Resource Type	Article
Subject	Genetics

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GENETIC FACTORS AND DIET AFFECT LONG BONE LENGTH IN THE F34 LG,SM ADVANCED INTERCROSS

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Fine-mapping alleles for body weight in LG/J × SM/J F2 and F34 advanced intercross lines

QTLs for murine red blood cell parameters in LG/J and SM/J F2 and advanced intercross lines

REPLICATION OF LONG BONE LENGTH QTL IN THE F9 - F10 LG,SM ADVANCED INTERCROSS

Fine-mapping alleles for body weight in LG/J × SM/J F2 and F34 advanced intercross lines

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Genetic factors and diet affect long-bone length in the F34 LG,SM advanced intercross

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