NDLI: A Cascade of epistatic interactions regulating teratozoospermia in mice

Content Provider	Springer Nature Link
Author	Hirawatari, Keitaro Hanzawa, Naoto Miura, Ikuo Wakana, Shigeharu Gotoh, Hideo
Copyright Year	2015
Abstract	Infertility in humans and subfertility in domestic animals are two major reproductive problems. Among human couples, ~15 % are diagnosed as infertile, and males are considered responsible in about 50 % of the cases. To examine male fertility, various sperm tests including analyses of sperm morphology, sperm count and sperm mobility are usually performed. Teratozoospermia, a condition characterized by the presence of morphologically abnormal sperm, is considered as a symptom of infertility. B10.MOL-TEN1 (TEN1) mice (Mus musculus) show inherited teratozoospermia at high frequencies (~50 %). In this study, the polygenic control of teratozoospermia in the TEN1 strain was analysed. A quantitative trait loci analysis indicated three statistically significant loci, Sperm-head morphology 3 (Shm3; logarithm of the odds (LOD) score, 29.25), Shm4 (LOD score, 6.80), and Shm5 (LOD score, 3.58). These three QTL peaks were mapped to 24.3 centimorgans (cM) on chromosome 1, 32.0 cM on chromosome X, and 63.8 cM on chromosome 6, respectively. Another locus that is yet to be determined was also predicted. Shm3 was found to be the major locus responsible for teratozoospermia, and a sequential cascade of interactions of the other three loci was apparent. These results are expected to help understand the mechanisms underlying reproductive problems in humans or domestic animals.
Starting Page	248
Ending Page	256
Page Count	9
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	26
Issue Number	5-6
e-ISSN	14321777
Language	English
Publisher	Springer US
Publisher Date	2015-05-12
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell Biology Anatomy Zoology
Content Type	Text
Resource Type	Article
Subject	Genetics

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