NDLI: Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal “DDK syndrome” genes are linked

Content Provider	Springer Nature Link
Author	Villena, Fernando Pardo Manuel Naumova, Anna K. Verner, Andrei E. Jin, Wen Hui Sapienza, Carmen
Copyright Year	1997
Abstract	The polar, preimplantation-embryo lethal phenotype known as the“DDK syndrome” in the mouse is the result of the complex interaction of genetic factors and a parental-origin effect. We previously observed a modest degree of transmission-ratio distortion in favor of the inheritance of DDK alleles in the Ovum mutant (Om) region of Chromosome (Chr) 11, among offspring of reciprocal F1-hybrid females and C57BL/6 males. In this study, we confirm that a significant excess of offspring inherit DDK alleles from F1 mothers and demonstrate that the preference for the inheritance of DDK alleles is not a specific bias against the C57BL/6 allele or a simple preference for offspring that are heterozygous at Om. Because none of the previous genetic models for the inheritance of the“DDK syndrome” predicted transmission-ratio distortion through F1 females, we reconsidered the possibility that the genes encoding the maternal and paternal components of this phenotype were not linked. We have examined the fertility phenotype of N2 females and demonstrate that the inter-strain fertility of these females is correlated with their genotype in the Om region. This result establishes, directly, that the genes encoding the maternal and paternal components of the DDK syndrome are genetically linked.
Starting Page	642
Ending Page	646
Page Count	5
File Format	PDF
ISSN	09388990
Journal	Mammalian Genome
Volume Number	8
Issue Number	9
e-ISSN	14321777
Language	English
Publisher	Springer-Verlag
Publisher Date	1997-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cell Biology Anatomy Zoology
Content Type	Text
Resource Type	Article
Subject	Genetics

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The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om

The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om

Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome.

Transmission-Ratio Distortion through F(1) Females at Chromosome 11 Loci Linked to Om in the Mouse Ddk Syndrome

Nondisjunction and transmission ratio distortion ofChromosome 2 in a (2.8) Robertsonian translocation mouse strain

The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3

Fluctuation in fertility phenotypes of the heterozygous (Om/+) mice owing to background genes

Exma: an X-linked insertional mutation that disrupts forebrain and eye development

Evidence of maternal QTL affecting growth and obesity in adult mice

Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal “DDK syndrome” genes are linked

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The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om

The maternal DDK syndrome phenotype is determined by modifier genes that are not linked to Om

Transmission-ratio distortion through F1 females at chromosome 11 loci linked to Om in the mouse DDK syndrome.

Transmission-Ratio Distortion through F(1) Females at Chromosome 11 Loci Linked to Om in the Mouse Ddk Syndrome

Nondisjunction and transmission ratio distortion ofChromosome 2 in a (2.8) Robertsonian translocation mouse strain

The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3

Fluctuation in fertility phenotypes of the heterozygous (Om/+) mice owing to background genes

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Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal “DDK syndrome” genes are linked