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| Content Provider | Springer Nature Link |
|---|---|
| Author | Moriyama, Yohsuke Yamazaki, Tomokazu mura, Hideo Sasaki, Narie Kawa, Shigeyuki |
| Copyright Year | 2005 |
| Abstract | The active, selective digestion of mtDNA from one parent is a possible molecular mechanism for the uniparental inheritance of mtDNA. In Physarum polycephalum, mtDNA is packed by DNA-binding protein Glom, which packs mtDNA into rod-shaped mt-nucleoids. After the mating, mtDNA from one parent is selectively digested, and the Glom began to disperse. Dispersed Glom was retained for at least 6 h after mtDNA digestion, but disappeared completely by about 12 h after mixing two strains. We identified two novel nucleases using DNA zymography with native-PAGE and SDS-PAGE. One is a Ca2+-dependent, high-molecular-weight nuclease complex (about 670 kDa), and the other is a Mn2+-dependent, high-molecular-weight nuclease complex (440–670 kDa); the activity of the latter was detected as a Mn2+-dependent, 13-kDa DNase band on SDS-PAGE. All mitochondria isolated from myxamoebae had mt-nucleoids, whereas half of the mitochondria isolated from the zygotes at 12 h after mixing had lost the mt-nucleoids. The activity of the Mn2+-dependent nuclease in the isolated mitochondria was detected at least 8 h after mixing of two strains. The timing and localization of the Mn2+-dependent DNase activity matched the selective digestion of mtDNA. |
| Starting Page | 334 |
| Ending Page | 343 |
| Page Count | 10 |
| File Format | |
| ISSN | 01728083 |
| Journal | Current Genetics |
| Volume Number | 48 |
| Issue Number | 5 |
| e-ISSN | 14320983 |
| Language | English |
| Publisher | Springer-Verlag |
| Publisher Date | 2005-10-08 |
| Publisher Place | Berlin, Heidelberg |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Isogamous mating Uniparental inheritance Mitochondrial transmission genetics Myxomycetes Proteomics Plant Sciences Cell Biology Biochemistry Microbiology Microbial Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine |
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